Khảo sát nồng độ 25-hydroxyvitamin D huyết thanh và một số yếu tố liên quan ở trẻ em mắc hội chứng thận hư tại Bệnh viện Nhi Trung ương

Abstract

The study titled as “Investigation of Serum 25-Hydroxyvitamin D Levels and Related Factors in Children with Nephrotic Syndrome at the Vietnam National Children’s Hospital” was conducted on 113 children aged 5 - 17 years old to assess vitamin D deficiency and its associated factors. The results showed that 96% of children with nephrotic syndrome had insufficient serum vitamin D levels, of which 64% were severely deficient. Vitamin D deficiency was statistically significantly associated with disease relapse stage and corticosteroid dosage - patients receiving corticosteroid doses greater than 1.5 mg/kg/day had the highest deficiency rate (88.9%). Additionally, there was a significant relationship between vitamin D deficiency and low total serum protein. Nevertheless, there was no statistically significant difference found between serum vitamin D levels across different treatment regimens. These findings highlight the need for screening and vitamin D supplementation as part of a comprehensive management strategy for children with nephrotic syndrome to reduce bone metabolism disorders and complications caused by long-term corticosteroid therapy.