Article Sidebar

PDF (Tiếng Việt)
Published: 2026-01-28
Abstract Views: 0
Views PDF (Tiếng Việt): 0
DOI: https://doi.org/10.52852/tcncyh.v198i1.4381
Issue
Vol. 198 No. 1 (2026)
Section
Các bài báo
How to Cite
Quyên, V. T., Nguyên, N. T., & Phương, V. H. (2026). Efficacy of tranexamic acid in minimizing perioperative blood loss during spinal surgery for tuberculous spondylitis. Journal of Medical Research, 198(1), 296-305. https://doi.org/10.52852/tcncyh.v198i1.4381

Efficacy of tranexamic acid in minimizing perioperative blood loss during spinal surgery for tuberculous spondylitis

Vu Thi Quyen, Ngo The Nguyen, Vu Hoang Phuong

Main Article Content

Abstract

Spinal surgery, particularly procedures for tuberculosis-related spinal disease, carries a high risk of intraoperative bleeding, which can lead to acute blood loss and serious complications. This study aimed to evaluate the effectiveness of tranexamic acid (TXA) in reducing intraoperative and postoperative blood loss in patients undergoing spinal surgery for tuberculous lesions. In this controlled clinical trial, 60 patients were divided into two groups: a TXA group (n = 30) and a control group without TXA administration (n = 30). Evaluation criteria included baseline characteristics, number of operated vertebral levels, duration of surgery, total infusion volume, and intraoperative and postoperative blood loss. Results showed that the mean intraoperative blood loss in the TXA group was 140.9 ± 15.8ml, significantly lower than in the control group (244.2 ± 13.7ml, p < 0.01). Postoperative blood loss at 12 hours was also markedly reduced in the TXA group (164.1 ± 31.4ml) compared with the control group (212.6 ± 28.2ml, p < 0.01). From 24 hours postoperatively until drain removal, blood loss remained lower in the TXA group (57.7 ± 14.3ml vs. 66.3 ± 8.5ml, p < 0.01). The study concludes that tranexamic acid significantly decreases both intraoperative and postoperative blood loss in spinal surgery for tuberculosis-related disease without prolonging operative time or delaying postoperative recovery. The use of TXA may therefore be considered a safe and effective strategy for preventing blood loss in this high-risk surgical population.

Article Details

Keywords

Tranexamic acid, spinal tuberculosis surgery, blood loss prevention

References

1. Bộ Môn Gây Mê Hồi Sức (2006), Bài Giảng Gây Mê Hồi Sức, Đại Học Y Hà Nội.
2. Todeschini AB, Uribe AA, Echeverria-Villalobos M, et al. Efficacy of Intravenous Tranexamic Acid in Reducing Perioperative Blood Loss and Blood Product Transfusion Requirements in Patients Undergoing Multilevel Thoracic and Lumbar Spinal Surgeries: A Retrospective Study. Front Pharmacol. 2020; 11: 566956. doi:10.3389/fphar.2020.566956.
3. Pernik MN, Dosselman LJ, Aoun SG, et al. The effectiveness of tranexamic acid on operative and perioperative blood loss in long-segment spinal fusions: a consecutive series of 119 primary procedures. J Neurosurg Spine. 2020; 32(5): 768-774. doi:10.3171/2019.11.SPINE191174.
4. Wang F, Nan L, Feng X, et al. The efficacy and safety of multiple-dose intravenous tranexamic acid in reducing perioperative blood loss in patients with thoracolumbar burst fracture. Clin Neurol Neurosurg. 2020; 193: 105766. doi:10.1016/j.clineuro.2020.105766.
5. Xue P, Yang J, Xu X, et al. The efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis: A retrospective observational study. Medicine (Baltimore). 2018; 97(50): e13643. doi:10.1097/MD.0000000000013643.
6. Đỗ Trung Dũng (2007), Đánh giá tác dụng giảm mất máu sau mổ tim mở của Tranexamic Acid dùng trong mổ, Luận văn Thạc sĩ Y học - ĐH Y Hà Nội.
7. Trịnh Văn Sơn (2015), Đánh giá tác dụng giảm chảy máu của Tranexamic acid trong phẫu thuật chấn thương gan nặng tại BV Việt Đức, Luận văn tốt nghiệp BSYK - ĐH Y Hà Nội.
8. A. B. Todeschini, A. A. Uribe, M. Echeverria-Villalobos, J. Fiorda-Diaz, M. Abdel-Rasoul, B. G. McGahan, A. J. Grossbach, S. Viljoen, và S. D. Bergese (2020), Efficacy of Intravenous Tranexamic Acid in Reducing Perioperative Blood Loss and Blood Product Transfusion Requirements in Patients Undergoing Multilevel Thoracic and Lumbar Spinal Surgeries: A Retrospective Study. Front Pharmacol, số 11, tr. 566956.
9. E. B. Gausden, M. R. Garner, S. J. Warner, A. Levack, A. M. Nellestein, T. Tedore, E. Flores, và D. G. Lorich (2016), Tranexamic acid in hip fracture patients: a protocol for a randomised, placebo controlled trial on the efficacy of tranexamic acid in reducing blood loss in hip fracture patients. BMJ Open, số 6(6), tr. e010676.
10. Li J, Wang L, Bai T, Liu Y, Huang Y. Combined use of intravenous and topical tranexamic acid efficiently reduces blood loss in patients aged over 60 operated with a 2-level lumbar fusion. J Orthop Surg. 2020; 15: 339. doi:10.1186/s13018-020-01758-8.
11. Ahmad Fauzi; Adam Moelyono; S Dohar Tobing (2018), Compared to Conventional Dressing Techniques, Tranexamic Acid Injection Provide Better Surgical Outcomes in Spinal Fusion Surgery. Biomedical Pharmacology Journal.
12. Chong Chen; Yong‑yu Ye1; Yi‑fan Chen1; Xiao‑xi Yang; Jin‑qian Liang; Guo‑yan Liang; và Xiao‑qing Zheng; Yun‑bing Chang (2022), Comparison of blood loss between tranexamic acid‑soaked absorbable Gelfoam and topical retrograde injection via drainage catheter plus clamping in cervical laminoplasty surgery. BMC Musculoskeletal Disorders, số 23:668.
13. S. Endres, M. Heinz, và A. Wilke (2011), Efficacy of tranexamic acid in reducing blood loss in posterior lumbar spine surgery for degenerative spinal stenosis with instability: a retrospective case control study. BMC Surg, số 11, tr. 29.