Đánh giá tác dụng bảo vệ của “chế phẩm lá bơ” trên mô hình loét dạ dày - tá tràng bằng Cysteamin ở động vật thực nghiệm

Abstract

Avocado leaves (Persea americana) have been used in traditional medicine in many countries worldwide due to their potential pharmacological properties. This study was conducted to evaluate the gastroprotective effect of the “Che pham La bo” (CPLB) on a cysteamine-induced gastric and duodenal ulcer model in Wistar rats. The rats were divided into five groups: normal control, ulcer control, positive control (famotidine 50 mg/kg/day), and CPLB at two dose levels (0.24 g/kg/day and 0.72 g/kg/day). All groups received the respective treatments orally for seven consecutive days. Ulcers were then induced by administering cysteamine at 400 mg/kg twice, four hours apart. After 24 hours, the animals were sacrificed for macroscopic observation, histopathological evaluation, and biochemical analysis (AST, ALT, urea, and creatinine). The results showed that cysteamine induced marked gastric and duodenal ulceration, with ulcer incidences of 90% and 100%, respectively. CPLB showed a clear protective effect on the cysteamine-induced gastric and duodenal ulcer model. In the stomach, CPLB at 0.24 g/kg/day reduced ulcer severity and number, and improved microscopic lesions. This effect increased significantly at 0.72 g/kg/day. In the duodenum, 0.72 g/kg/day dose reduced the incidence and depth of ulcers with statistical significance, whereas a low dose showed only a tendency to improve. Thus, “Che pham La bo” has a protective effect on the cysteamine-induced gastric and duodenal ulcers in the experiment.