Article Sidebar

PDF (Tiếng Việt)
Published: 2026-01-28
Abstract Views: 0
Views PDF (Tiếng Việt): 0
DOI: https://doi.org/10.52852/tcncyh.v198i1.4397
Issue
Vol. 198 No. 1 (2026)
Section
Các bài báo
How to Cite
Nga, Đỗ T. T., Đức, N. S., Hoài, T. H. T., Nhật, Đặng Q., & Linh, N. T. T. (2026). Epidemiological and clinical characteristics and risk factors for severe disease in children with measles at Ha Noi Children Hospital, 2024 - 2025. Journal of Medical Research, 198(1), 539-547. https://doi.org/10.52852/tcncyh.v198i1.4397

Epidemiological and clinical characteristics and risk factors for severe disease in children with measles at Ha Noi Children Hospital, 2024 - 2025

Do Thi Thuy Nga, Nguyen Sy Duc, Tran Hoang Thi Hoai, Dang Quang Nhat, Nguyen Thi Tu Linh

Main Article Content

Abstract

Measles is an acute infectious disease caused by the measles virus, which can lead to severe complications and fatality. This study described the epidemiological and clinical characteristics of children with measles at the Hanoi Children Hospital in 2024 - 2025. A total of 659 cases were collected, with the age group under 9 months old accounting for the highest proportion (43.7%) and a male-to-female ratio of 1.7:1. More than 57.4% of the children were unvaccinated, and 8.2% had underlying diseases. The most common complication was pneumonia (80.1%), followed by gastroenteritis (56%). Respiratory failure occurred in 110 children (16.7%). Children with underlying diseases had a 3.69-fold higher risk of developing severe complications (95% CI: 2.04 - 6.67; p < 0.001) and high fever (> 39°C) increased the risk by 1.57 times (95% CI: 1.02 - 2.42; p = 0.039).

Article Details

Keywords

Measles, respiratory failure, severe complication

References

1. Bộ Y tế (2025). Hướng dẫn chẩn đoán và điều trị bệnh sởi (Ban hành kèm theo Quyết định số 1019/QĐ-BYT ngày 26 tháng 3 năm 2025)
2. Centers for Disease Control and Prevention (CDC). Measles Symptoms and Complications. Measles (Rubeola). September 11, 2025. Accessed October 10, 2025. https://www.cdc.gov/measles/signs-symptoms/index.html.
3. Dattani S, Spooner F. Measles vaccines save millions of lives each year. Our World in Data. Published online May 19, 2025. Accessed October 5, 2025. https://ourworldindata.org/measles-vaccines-save-lives.
4. Đỗ Phương Loan, Triệu Thị Thanh Vân, Duyên Thị Mai Nguyên, et al. Epidemiological and molecular characteristics of a measles outbreak in northern Vietnam, 2013-2014. Journal of Clinical Virology. 2021; 139: 104840. doi:10.1016/j.jcv.2021.104840.
5. Measles - an overview | ScienceDirect Topics. Accessed October 14, 2025. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/measles.
6. Wang X, Boulton ML, Montgomery JP, et al. The epidemiology of measles inTianjin, China, 2005-2014. Vaccine. 2015; 33(46): 6186-6191. doi:10.1016/j.vaccine.2015.10.008.
7. Sindhu T, Geeta M, Krishnakumar P, Sabitha S, Ajina K. Clinical profile of measles in children with special reference to infants. Trop Doct. 2019; 49(1): 20-23. doi:10.1177/0049475518804695.
8. Domai FM, Agrupis KA, Han SM, et al. Measles outbreak in the Philippines: epidemiological and clinical characteristics of hospitalized children, 2016-2019. Lancet Reg Health West Pac. 2021; 19: 100334. doi:10.1016/j.lanwpc.2021.100334.
9. Edwards KM. Maternal antibodies and infant immune responses to vaccines. Vaccine. 2015; 33(47): 6469-6472. doi:10.1016/j.vaccine.2015.07.085.
10. Waaijenborg S, Hahné SJM, Mollema L, et al. Waning of maternal antibodies against measles, mumps, rubella, and varicella in communities with contrasting vaccination coverage. J Infect Dis. 2013; 208(1): 10-16. doi:10.1093/infdis/jit143.
11.Bộ Y Tế. Quyết định 271/QĐ-BYT 2025 Kế hoạch triển khai chiến dịch tiêm chủng vắc xin phòng chống dịch Sởi.
12. Moss WJ. Measles. The Lancet. 2017; 390(10111): 2490-2502. doi:10.1016/S0140-6736(17)31463-0.
13. World Health Organization (WHO). Measles. Accessed October 14, 2025. https://www.who.int/news-room/fact-sheets/detail/measle
14. Trachsel D, Erb TO, Hammer J, von Ungern-Sternberg BS. Developmental respiratory physiology. Paediatr Anaesth. 2022; 32(2): 108-117. doi:10.1111/pan.14362.
15. Mortola JP. Influence of temperature on metabolism and breathing during mammalian ontogenesis. Respiratory Physiology & Neurobiology. 2005; 149(1): 155-164. doi:10.1016/j.resp.2005.01.012.
16. Huỳnh Ngọc Linh, Ngô Quốc Thống. Dịch tễ và một số đặc điểm bệnh Sởi tại tỉnh Cà Mau giai đoạn 2015-2024. YHCĐ. 2025;66(CĐ3-HNKH Ký Sinh Trùng VN lần thứ 51). doi:10.52163/yhc.v66iCĐ3.2173.
17. Đặng Quốc Duy, Nguyễn An Nghĩa. Đặc điểm điều trị bệnh nhi Sởi biến chứng viêm phổi nặng tại Bệnh viện Nhi Đồng 1. Tạp chí Y học Thành phố Hồ Chí Minh. 2021; tr.89-94 - ISSN.1859-1779. https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/168673.