Nghiên cứu tác dụng bảo vệ gan và chống oxy hóa của Saphia Alkali K90 trên thực nghiệm

Abstract

Saphia Alkali K90 was a novel product containing a mixture of herbal components, including Celastrus hindsii Benth et Hook, Pseuderanthemum palatiferum Radlk, Hedyotis diffusa Willd…; targeting the support of liver disease treatment, such as hepatitis and cirrhosis. The study aimed to evaluate the hepatoprotective and antioxidant activities of Saphia Alkali K90 in the experiment. Mice were randomly divided into five groups of ten mice per cage representing the control, model (negative control), positive control (silymarin-140 mg/kg), and Saphia Alkali K90 at two doses of 18 mL/kg/day and 36 mL/kg/day. Mice were orally given an administration of researched products and distilled water for 8 consecutive days. On the 8th day, after 2 hours of the administration, mice in groups 2, 3, 4, and 5 were given an oral administration of paracetamol 400 mg/kg to induce liver cell damage. 48 hours later, all indices, including AST, ALT, GGT levels, albumin, total bilirubin concentration, liver MDA concentration, liver weight, macroscopic and microscopic analyses of livers were evaluated. As a result, Saphia Alkali K90 at both doses posed the hepatoprotective effect on paracetamol-induced liver injury through the decrease of AST, ALT, and GGT levels, an increase of albumin concentration, a decrease of the liver weight, an improvement of macroscopic and microscopic images of livers, and a reduction of MDA level in the liver homogenate as compared with the model group.