Insulin resistance and non-alcoholic fatty liver disease among elderly patients attending Military Hospital 175
Main Article Content
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder in the elderly, in which insulin resistance plays a central role in the pathogenesis and progression of the disease. In Vietnam, data on insulin resistance and its association with NAFLD in older adults remain limited, particularly in the context of a rapidly aging population and the increasing burden of metabolic diseases. A cross-sectional study was conducted on 404 patients aged ≥ 60 years old who visited the Senior Officials Clinic at Military Hospital 175 from August 2024 to June 2025. Results showed that insulin levels, HOMA-IR, and the rate of insulin resistance all increased with the severity of NAFLD (p < 0.01); the prevalence of insulin resistance rose from 11.7% in the non-NAFLD group to 88.9% in the NAFLD grade 3 group. HOMA-IR showed moderate predictive value for NAFLD (AUC = 0.76), with an optimal cutoff of 2.05. These findings highlight the central role of insulin resistance in the pathogenesis of NAFLD among older adults. Early detection and management of insulin resistance should be prioritized as key strategies for the prevention and control of NAFLD in this population.
Article Details
Keywords
NAFLD, elderly, insulin resistance
References
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