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Published: 2026-01-28
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DOI: https://doi.org/10.52852/tcncyh.v198i1.4535
Issue
Vol. 198 No. 1 (2026)
Section
Các bài báo
How to Cite
Vân, P. T. H., Thạch, H. N., Văn, N. A. ., Thu, L. P., & Hoa, N. P. A. (2026). The value of histology in the prognosis of patients with biliary atresia after Kasai’s surgery. Journal of Medical Research, 198(1), 420-428. https://doi.org/10.52852/tcncyh.v198i1.4535

The value of histology in the prognosis of patients with biliary atresia after Kasai’s surgery

Pham Thi Ha Van, Hoang Ngoc Thach, Nguyen Anh Van, Le Phong Thu, Nguyen Pham Anh Hoa

Main Article Content

Abstract

This descriptive study involved 65 patients with biliary atresia who underwent Kasai surgery at the NCH from 5/2022 to 4/2024, aiming to assess the value of histological prognosis after Kasai’s surgery in patients with biliary atresia. The mean follow-up time was 13.14 ± 4.73 months (6.0 - 23 months). The success rate was 56.9% after 6 months. The mean time to successful biliary drainage was 2.5 ± 1.6 months. Several histopathological features at the time of surgery influenced long-term prognosis, including patients with grade III-IV cirrhosis having higher APRI and FIB-4 scores compared to the grade I-II cirrhosis group (5 vs. 1.7; 0.17 vs. 0.07, p18 < 0.05). Patients with moderate-to-severe giant cell degenerative lesions had a higher median PELD score compared to the group with mild giant cell degenerative lesions (19.67 ± 8.7 vs. 1.01 ± 10.81, p18 < 0.05). Patients with moderate-to-severe giant cell degenerative lesions and the group with DPM (Dutal plate malformation) had a lower cumulative 18-month survival probability compared to the group with mild giant cell degenerative lesions (39% vs. 100%, p = 0.006) and the group without DPM (61% vs. 83%, p = 0.038).

Article Details

Keywords

Biliary atresia, Kasai operation, Histological, Liver fibrosis, PELD

References

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