STAT4 rs7574865 polymorphism and its association with systemic lupus erythematosus
Main Article Content
Abstract
STAT4 gene polymorphism rs7574865 is associated with Systemic Lupus Erythematosus (SLE) which is a complex, multi-organ autoimmune disease. This study aimed to determine the association between the STAT4 rs7574865 polymorphism and SLE. This was a cross-sectional study involving 147 SLE patients and 159 healthy controls recruited at Cho Ray Hospital. STAT4 rs7574865 genotyping was performed using the Sanger sequencing technique. The results showed that the frequency of the T allen was significantly higher in the SLE group (48.30%) compared to the control group (33.96%) (p < 0.001). The T allen was associated with an increased risk of developing SLE, with an OR of 1.82 (95% CI: 1.31 – 2.52; p < 0.001). The GT and TT genes also showed a significant association with the risk of developing SLE compared to the reference GG gene (ORGT = 2.16, p = 0.003; ORTT = 2.89, p = 0.001). This is the first study in the Vietnamese population regarding the STAT4 rs7574865 polymorphism, providing additional genetic data to both national and global literature.
Article Details
Keywords
Systemic lupus erythematosus, STAT4, Sanger sequencing, Vietnamese patients
References
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