Evaluation of treatment outcomes of partial supraspinatus tendon tears using ultrasound-guided local type I collagen injections at E Hospital

Hoang Thi Nhung, Dang Chi Hieu, Phung Duc Tam, Pham Thi Mai Quyen, Ngo Thi Thuc Nhan, Nguyen Vinh Ngoc

Main Article Content

Abstract

Shoulder pathology is increasingly prevalent and significantly impacts quality of life. Currently, local collagen injection therapy is utilized in the management of partial supraspinatus tendon tears. This study aims to evaluate the outcomes of treating partial supraspinatus tendon tears using ultrasound-guided Type I Collagen injections. This prospective, interventional study was conducted on 52 patients (53 shoulders) diagnosed with partial supraspinatus tendon tears at the Department of Rheumatology, E Hospital, from August 2024 to June 2025. Patients received ultrasound-guided injections of Type I Collagen (2ml /week) for 5 consecutive weeks, with a follow-up assessment at 12 weeks. The results showed a reduction in the VAS score by 75.64% and the SPADI score by 78.47%, while the shoulder abduction angle increased by 27.09% (p < 0.001). Ultrasound evaluation indicated a 49.5% reduction in tear area and a 29.5% reduction in thickness. Mild local pain was reported in 11.3% of patients, with no serious complication observed. Ultrasound-guided Type I Collagen injection therapy is effective in reducing pain, improving range of motion, and supporting tendon structural regeneration, with a favorable safety profile.

Article Details

References

1. Đỗ Gia Tuyển, Trần Ngọc Ánh. Bệnh học nội khoa. Tập 2. Nhà xuất bản Y học; 2022: 300-304.
2. Milgrom C, et al. The effect of age, hand dominance and gender. J Bone Joint Surg Br. 1995;77(2):296-298.
3. Corrado B, et al. Ultrasound-guided collagen injections in the treatment of supraspinatus tendinopathy: a case series pilot study. J Biol Regul Homeost Agents. 2020;34:33-39.
4. Randelli F, et al. Effect of a collagen-based compound on morpho-functional properties of cultured human tenocytes. Cells. 2018;7(12):246.
5. Friedrichs J, Taubenberger A, Franz CM, et al. Cellular remodelling of individual collagen fibrils visualized by time-lapse AFM. J Mol Biol. 2007;372(3):594-607. doi:10.1016/j.jmb.2007.06.078
6. Rahman AU, Nasim S, Baig I, et al. Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica. J Ethnopharmacol. 2003;86(2-3):177-180. doi:10.1016/s0378-8741(03)00055-2
7. Nestorova R, et al. Clinical and sonographic assessment of the effectiveness of Guna Collagen MDs injections in patients with partial thickness tear of the rotator cuff. Physiol Regul Med. 2017.
8. Nestorova R, Todorov P, Petranova T, et al. Bulgarian experience with injectable Collagen Guna medical devices in shoulder periarthritis. Physiol Regul Med. 2021: 9-15
9. Ngô Thị Thu Trang. Đánh giá kết quả điều trị rách bán phần gân trên gai bằng liệu pháp tiêm collagen trọng lượng phân tử thấp. Luận vân chuyên khoa cấp II, Nội Khoa, Đại Học Y Hà Nội. 2024.