Factor associated with respiratory failure with early-onset neonatal sepsis

Mai Kieu Anh, Dao Thi Ngoan, Hoang Quynh Lan, Nguyen Thuy Ha, Ngo Van Dan, Duong Thi Dung, Dam Thi Quynh, Dang Thu Thuy

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Abstract

Early-onset neonatal sepsis is a severe and rapidly progressive condition in which respiratory failure is a common and potentially life-threatening manifestation. However, clinical and laboratory signs of respiratory failure in this group are often nonspecific, causing a challenge in early detection. A cross-sectional descriptive study was conducted at Vinmec Times City International Hospital to identify factors associated with respiratory failure in neonates diagnosed with early-onset neonatal sepsis. The results showed that the incidence of respiratory failure was 61.3% where 34.2% required oxygen support, 55.3% required CPAP, and 10.5% required invasive mechanical ventilation. Factors associated with respiratory failure included preterm birth, low birth weight, and a 1-minute Apgar score below 7, while routine laboratory parameters showed no significant correlation. These findings highlight the need for intensive respiratory monitoring from the early stages, particularly in high-risk neonates, to improve care and outcomes.

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References

1. Zheng Q, Zhang R, Dong W. Global, regional, and national burden of neonatal sepsis and other neonatal infections, 1990 - 2021: findings from the Global Burden of Disease Study 2021. European Journal of Pediatrics. 2023; 182:2335 - 2343.
2. Joshi NS, Huynh K, Lu T, et al. Epidemiology and trends in neonatal early-onset sepsis in California, 2010-2017. J Perinatol. 2022; 42: 940 - 946.
3. Paraparambil Vellamgot A, Thyvilayil Salim S, Salameh K, et al. Epidemiology of early-onset neonatal sepsis in Qatar, 2015-2022: a multicentre retrospective cohort study. BMJ Paediatr Open. 2025; 9(1). Published June 27, 2025.
4. Van Veen LEJ, van der Weijden BM, Achten NB, et al. Incidence of antibiotic exposure for suspected and proven neonatal early-onset sepsis between 2019 and 2021: a retrospective, multicentre study. Antibiotics (Basel). 2024; 13(6): 537. Published June 10, 2024.
5. Sands K, Spiller OB, Thomson K, et al. Early-onset neonatal sepsis in low- and middle-income countries: current challenges and future opportunities. Infect Drug Resist. 2022; 15:933-946. Published March 9, 2022.
6. Trần Lương Nhân, Nguyễn Thị Quỳnh Nga. Đặc điểm lâm sàng, cận lâm sàng của nhiễm khuẩn huyết ở trẻ sơ sinh tại khoa Sơ sinh Bệnh viện Phụ sản Hà Nội. Tạp chí Y học Việt Nam. 2024; 542(2).
7. Nguyễn Thị Ngọc Tú, Trương Thị Mai Hồng, Lê Ngọc Duy, và cs. Đánh giá kết quả điều trị nhiễm khuẩn huyết sơ sinh đủ tháng tại Bệnh viện Nhi Trung ương (2019-2021) và một số yếu tố liên quan. Tạp chí Y học Cộng đồng. 2022; 63(2).
8. Phan Thị Thúy Tuệ, Phạm Vân Anh, Nguyễn Đình Tuyến. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và một số yếu tố liên quan đến suy hô hấp sơ sinh nặng tại Bệnh viện Sản - Nhi tỉnh Quảng Ngãi. Tạp chí Y học Việt Nam. 2023; 529(1).
9. National Institute for Health and Care Excellence (NICE). Neonatal infection: determining the need for antibiotic treatment of babies within 72 hours of birth. Neonatal infection: antibiotics for prevention and treatment. NICE guideline; 2021.
10. Gebreheat G, Tadesse B, Teame H. Predictors of respiratory distress syndrome, sepsis, and mortality among preterm neonates admitted to neonatal intensive care unit in northern Ethiopia. J Pediatr Nurs. 2022; 63.
11. Asadollahi K, Karimi A, Rezaei N, et al. The Apgar score: a predictor of clinical adverse outcomes during the neonatal period. Ilam Univ Med Sci J. 2024; 11(2): 22.
12. Wang B, Wang QM, Li DX. An analysis of predictive factors for severe neonatal infection and the construction of a prediction model. Infect Drug Resist. 2023; 16: 3561-3574.
13. Iwai M, Yoshimatsu H, Naramura T, et al. Procalcitonin is associated with postnatal respiratory condition severity in preterm neonates. Pediatr Pulmonol. 2022; 57(5): 1272-1281.
14. Yilmaz A, Kaya N, Gonen I, et al. Evaluating neonatal early-onset sepsis through lactate and base excess monitoring. Scientific Reports. 2023; 13:14837. Published September 8, 2023.