Recovery effects of S-men in male mice with reproductive impairment induced by sodium valproate
Main Article Content
Abstract
This study was conducted to evaluate the restorative effects of the S-Men formulation on the reproductive function of adult male mice with reproductive impairment induced by sodium valproate (NVP). The animals were orally administered NVP at 500 mg/kg/day for 5 consecutive weeks. After model induction, mice received S-Men at 1096 mg/kg/day and 2192 mg/kg/day for 14 consecutive days. The evaluated parameters included male reproductive organs weights, serum testosterone concentration, sperm count and quality, oxidative stress indices, and histological morphology of the testes. The results showed that S-Men, particularly at 2192 mg/kg/day, significantly restored the reproductive disorders caused by sodium valproate. This was reflected in the recovery of reproductive organ weights, increased testosterone levels, improvement in sperm count and morphology, enhanced antioxidant capacity, and reduced histological damage in the testes. In female mice mated with treated males, the pregnancy rate and offspring development showed no statistically significant differences among groups. These findings indicate that S-Men markedly restored reproductive function in male mice with sodium valproate-induced reproductive impairment, with better efficacy observed at the dose of 2192 mg/kg/day.
Article Details
Keywords
S-Men, sodium valproate, mice, testosterone, reproductive impairment
References
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