Factors associated with sarcopenia in elderly patients with primary knee osteoarthritis

Vu Thi Huyen, Nguyen Ngoc Tam, Dinh Thi Huong, Nguyen Trung Anh

Main Article Content

Abstract

Sarcopenia and knee osteoarthritis are two commonly described musculoskeletal disorders, associated with numerous adverse health outcomes such as reduced physical function, disability, increased hospitalization, and mortality. This study was conducted on 221 older patients with primary knee osteoarthritis (KOA) to identify factors associated with sarcopenia. KOA was diagnosed according to the 1987 American College of Rheumatology criteria, while sarcopenia was defined based on the 2019 Asian Working Group for Sarcopenia guidelines (AWGS 2019). The study population had a mean age of 72.80 ± 8.13 years old, with a male-to-female ratio of approximately 1:6. Multivariable analysis showed that older age, osteoporosis, and malnutrition were independently associated with sarcopenia (p < 0.05). Conclusion: Advanced age, osteoporosis, and malnutrition are associated with sarcopenia in elderly patients with primary KOA, and early screening for sarcopenia is recommended in this population.

Article Details

References

1. Chen LK, Woo J, Assantachai P, et al. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc. 2020; 21(3): 300-307.e2. doi:10.1016/j.jamda.2019.12.012.
2. Pickering ME, Chapurlat R. Where Two Common Conditions of Aging Meet: Osteoarthritis and Sarcopenia. Calcif Tissue Int. 2020; 107(3): 203-211. doi:10.1007/s00223-020-00703-5.
3. Peng P, Wu J, Fang W, et al. Association between sarcopenia and osteoarthritis among the US adults: a cross-sectional study. Sci Rep. 2024; 14: 296. doi:10.1038/s41598-023-50528-z.
4. Kim HT, Kim HJ, Ahn HY, et al. An analysis of age-related loss of skeletal muscle mass and its significance on osteoarthritis in a Korean population. Korean J Intern Med. 2016; 31(3): 585-593. doi:10.3904/kjim.2015.156.
5. Lee SY, Ro HJ, Chung SG, et al. Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis. Alway SE, ed. PLoS ONE. 2016; 11(11): e0166385. doi:10.1371/journal.pone.0166385.
6. ACR Diagnostic Guidelines. Johns Hopkins Arthritis Center. Accessed June 16, 2021. https://www.hopkinsarthritis.org/physician-corner/education/arthritis-education-diagnostic-guidelines/.
7. Nguyen TN, Nguyen TN, Nguyen AT, et al. Prevalence of sarcopenia and its associated factors in patients attending geriatric clinics in Vietnam: a cross-sectional study. BMJ Open. 2020; 10(9): e037630. doi:10.1136/bmjopen-2020-037630.
8. Kirk B, Feehan J, Lombardi G, et al. Muscle, Bone, and Fat Crosstalk: the Biological Role of Myokines, Osteokines, and Adipokines. Curr Osteoporos Rep. 2020; 18(4): 388-400. doi:10.1007/s11914-020-00599-y.
9. Nielsen BR, Abdulla J, Andersen HE, et al. Sarcopenia and osteoporosis in older people: a systematic review and meta-analysis. Eur Geriatr Med. 2018; 9(4): 419-434. doi:10.1007/s41999-018-0079-6.
10. Wang X, Hunter DJ, Jin X, et al. The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials. Osteoarthritis Cartilage. 2018; 26(2): 165-174. doi:10.1016/j.joca.2017.11.015.