HPV Genotype Distribution and Associated Factors Among HPV-DNA-Positive Women at University Medical Center Ho Chi Minh City, 2025

Nguyen Huu Trung, Nguyen Thi Minh Hieu, Nguyen Thi Nhat Phuong, Hua Kim Tuyen, Bui Thi Kim Thao, Le Huu Thuy Trang, Ho Tran Loc Hoa, Nguyen Thanh Tram, Nguyen Thien Minh, Tran Thi Thanh Loan

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Abstract

A study was conducted on 390 women with positive HPV-DNA test results at the University Medical Center Ho Chi Minh City - Branch 2 in 2025 to investigate the distribution of HPV genotypes and associated factors. The results showed that HPV-52 was the most prevalent genotype (39.0%), followed by HPV-16 (22.3%) and HPV-58 (21.3%). Multiple infections (≥ 2 genotypes) accounted for 35.1% of cases, and 77.2% of participants had never received HPV vaccination. The proportion of unvaccinated individuals was 77.2%. The rate of unvaccinated women in the study population was high (77.2%), while demographic factors and vaccination history did not demonstrate a statistically significant protective association due to sample size limitations. Other factors, such as marital status or completion of the 3-dose vaccine series, did not show statistically significant associations in this study. The high prevalence of non-16/18 HPV genotypes highlights the need to consider implementing extended HPV genotyping in screening strategies that align with local epidemiological characteristics.

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