Experimental study on acute and sub-chronic toxicity of da day Phuong Dong herbal product
Main Article Content
Abstract
Da Day Phuong Dong is a polyherbal product intended for the treatment of peptic ulcers and acute and chronic gastroesophageal reflux disease. The objective of this study was to evaluate the acute and sub-chronic toxicity of Da Day Phuong Dong capsules experimentally. Acute toxicity was evaluated in Swiss mice by administering escalating doses to determine the lowest dose causing 100% mortality and the highest dose causing no mortality. Sub-chronic toxicity was evaluated in Wistar rats at 0.48 capsules (equivalent to the intended clinical dose) and 1.44 capsules/kg/day (3 times the clinical dose) for 4 continuous weeks. The results showed that Da Day Phuong Dong at a dose of 50 capsules/kg caused no mortality and no abnormal sign in Swiss mice; at 0.48 capsules and 1.44 capsules/kg, it did not affect the general condition, body weight of the Wistar rats, or the hematological parameters, biochemical indices, and microscopic morphology of the liver and kidneys. Thus, Da Day Phuong Dong does not cause acute or sub-chronic toxicity when administered orally at the tested doses in experimental animals.
Article Details
Keywords
Da Day Phuong Dong, acute toxicity, sub-chronic toxicity, peptic ulcer, Swiss mice, Wistar rats
References
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