Mối liên quan giữa nồng độ sST2 huyết thanh và tình trạng sung huyết theo thang điểm Rohde ở bệnh nhân đợt cấp suy tim mạn

Abstract

Congestion is a hallmark clinical manifestation and a crucial prognostic factor in patients with acute decompensated chronic heart failure. However, its accurate clinical assessment remains challenging. This prospective cohort study was conducted on 79 patients to determine the association between serum soluble ST2 (sST2) concentrations and congestion quantified by the Rohde score. The results showed that the prevalence of clinical congestion (Rohde score ≥ 5) was 48.1%. The mean serum sST2 concentration was 28.26 ± 8.27 ng/mL. Multivariate logistic regression analysis demonstrated that every 5 ng/mL increase in sST2 levels was associated with a 1.33-fold increase in the risk of severe congestion (OR = 1.33; 95% CI: 1.02 - 1.82; p = 0.048). These findings confirm that sST2 is an independent factor reflecting congestion burden and mechanical stress, providing additive value to clinical assessment.