Nồng độ sST2 huyết thanh và một số yếu tố liên quan ở bệnh nhân suy tim phân suất tống máu giảm sau nhồi máu cơ tim

Abstract

This study aimed to investigate serum soluble ST2 concentrations and associated factors in patients with chronic heart failure with reduced ejection fraction following myocardial infarction. A cross sectional analytic study was conducted in 77 patients. The median age was 71.0 years, and 53.2% were male. Most patients had hypertension (93.5%), one third had diabetes mellitus (33.8%), and 15.6% had dyslipidemia. Serum sST2 concentrations increased progressively across New York Heart Association functional classes from II to IV with statistical significance (p = 0.005. Multivariable linear regression analysis identified atrial fibrillation and New York Heart Association class III to IV as independent factors associated with serum sST2 concentrations p = 0.028 and p = 0.005, respectively. In conclusion, the median serum sST2 concentration in patients with heart failure with reduced ejection fraction after myocardial infarction was 22.3 ng/mL. Atrial fibrillation and heart failure severity as assessed by the New York Heart Association classification were independently associated with serum sST2 concentrations.