A review of the prognostic role of cardiac, lung, and diaphragm ultrasound in weaning from mechanical ventilation in Intensive Care Unit
Main Article Content
Abstract
Weaning from mechanical ventilation is a critical step in the management of critically ill patients, with extubation failure being associated with increased complications and mortality. Weaning failure is typically the result of multifactorial interactions among hemodynamic disturbances, loss of lung aeration and pulmonary edema, and impaired respiratory muscle function. This narrative review summarizes current evidence on the prognostic role of cardiac, lung, and diaphragmatic ultrasound in predicting weaning outcomes. Cardiac ultrasound helps identify elevated left ventricular filling pressures, lung ultrasound reflects loss of aeration and pulmonary congestion, while diaphragmatic ultrasound assesses respiratory muscle reserve. A multimodal ultrasound approach (cardiac–lung–diaphragm) represents a promising strategy - particularly in high-risk patients such as those with cardiovascular disease, after a major surgery, or prolonged mechanical ventilatio - using a dynamic assessment before and during spontaneous breathing trials and after extubation. However, due to the lack of standardized models and heterogeneity across studies, clinical application requires adequate training, standardized measurement protocols, and integration with overall clinical assessment. Further prospective, multicenter studies are needed to clarify the role of each parameter in specific patient populations.
Article Details
Keywords
weaning, cardiac ultrasound, lung ultrasound, diaphragm ultrasound, prognosis
References
2. Perren A, Brochard L. Managing the apparent and hidden difficulties of weaning from mechanical ventilation. Intensive Care Med 2013;39(11):1885-1895. doi:10.1007/s00134-013-3014-9.
3. Santangelo E, Mongodi S, Bouhemad B, et al. The weaning from mechanical ventilation: a comprehensive ultrasound approach. Curr Opin Crit Care 2022;28(3):322-330. doi:10.1097/mcc.0000000000000941.
4. Boles JM, Bion J, Connors A, et al. Weaning from mechanical ventilation. Eur Respir J. 2007;29(5):1033-1056. doi:10.1183/09031936.00010206.
5. Nicolotti D, Grossi S, Nicolini F, et al. Difficult Respiratory Weaning after Cardiac Surgery: A Narrative Review. J Clin Med 2023;12(2). doi:10.3390/jcm12020497.
6. Lagier D, Zeng C, Fernandez-Bustamante A, et al. Perioperative Pulmonary Atelectasis: Part II. Clinical Implications. Anesthesiology 2022;136(1):206-236. doi:10.1097/aln.0000000000004009.
7. Sanfilippo F, Di Falco D, Noto A, et al. Association of weaning failure from mechanical ventilation with transthoracic echocardiography parameters: a systematic review and meta-analysis. Br J Anaesth 2021;126(1):319-330. doi:10.1016/j.bja.2020.07.059.
8. Lamia B, Maizel J, Ochagavia A, et al. Echocardiographic diagnosis of pulmonary artery occlusion pressure elevation during weaning from mechanical ventilation. Crit Care Med 2009;37(5):1696-1701. doi:10.1097/CCM.0b013e31819f13d0.
9. Liu J, Shen F, Teboul JL, et al. Cardiac dysfunction induced by weaning from mechanical ventilation: incidence, risk factors, and effects of fluid removal. Crit Care 2016;20(1):369. doi:10.1186/s13054-016-153 3-9.
10. Santonocito C, Messina S, Zawadka M, et al. Left ventricular systolic function and mechanical ventilation weaning failure: An updated systematic review and meta-analysis with trial sequential analysis. Med Intensiva (Engl Ed) 2025:502231. doi:10.1016/j.medine.2025.502231.
11. Hajjar L, Lara T, Almeida J, et al. High levels of B-type natriuretic peptide predict weaning failure from mechanical ventilation in adult patients after cardiac surgery. Crit Care 2012;16(Suppl 1)(P127). doi:10.1186/cc10734.
12. Dres M, Teboul JL, Anguel N, et al. Extravascular lung water, B-type natriuretic peptide, and blood volume contraction enable diagnosis of weaning-induced pulmonary edema. Crit Care Med 2014;42(8):1882-1889. doi:10.1097/ccm.0000000000000295.
13. Zhang Z, Guo L, Wang H, et al. Diagnostic accuracy of lung ultrasound to predict weaning outcome: a systematic review and meta-analysis. Front Med (Lausanne) 2024;11:1486636. doi:10.3389/fmed.2024.1486636.
14. Soummer A, Perbet S, Brisson H, et al. Ultrasound assessment of lung aeration loss during a successful weaning trial predicts postextubation distress*. Crit Care Med 2012;40(7):2064-2072. doi:10.1097/CCM.0b013e31824e68ae.
15. Pecanha Antonio AC, Souza Castro P, Schulz LF, et al. Lung ultrasound findings predict weaning failure from mechanical ventilation. Crit Care 2014;14(18(Suppl 1)):298. doi:10.1186/cc13488.
16. Alansary AM, Hakim KY. Role of lung ultrasound in weaning from mechanical ventilation in postoperative neurosurgical ICU patients. Sri Lankan Journal of Anaesthesiology 2020;28(1):25-30. doi:10.4038/slja.v28i1.8481.
17. Rouby J-J, Perbet S, Quenot J-P, et al. Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial. Critical Care 2024;28(1):391. doi:10.1186/s13054-024-05166-w.
18. Zambon M, Beccaria P, Matsuno J, et al. Mechanical Ventilation and Diaphragmatic Atrophy in Critically Ill Patients: An Ultrasound Study. Crit Care Med 2016;44(7):1347-1352. doi:10.1097/ccm.0000000000001657.
19. Mahmoodpoor A, Fouladi S, Ramouz A, et al. Diaphragm ultrasound to predict weaning outcome: systematic review and meta-analysis. Anaesthesiol Intensive Ther 2022;54(2):164-174. doi:10.5114/ait.2022.117273.
20. Parada-Gereda HM, Tibaduiza AL, Rico-Mendoza A, et al. Effectiveness of diaphragmatic ultrasound as a predictor of successful weaning from mechanical ventilation: a systematic review and meta-analysis. Crit Care 2023;27(1):174. doi:10.1186/s13054-023-04430-9.
21. Spadaro S, Grasso S, Mauri T, et al. Can diaphragmatic ultrasonography performed during the T-tube trial predict weaning failure? The role of diaphragmatic rapid shallow breathing index. Crit Care 2016;20(1):305. doi:10.1186/s13054-016-1479-y.
22. Hasanin A, Helmy MA, Aziz A, et al. The ability of diaphragmatic excursion after extubation to predict the need for resumption of ventilatory support in critically ill surgical patients. J Anesth 2025;39(2):189-197. doi:10.1007/s00540-024-03442-1.
23. Busayarasamee S, Chittawatanarat K, Wannasopa Y. Ultrasonic Assessment of Diaphragm Function in the Ventilator Liberation of Perioperative Patients. The THAI Journal of SURGERY 2025;46(2):83-90. doi:10.64387/tjs.2025.271718.
24. Moury PH, Cuisinier A, Durand M, et al. Diaphragm thickening in cardiac surgery: a perioperative prospective ultrasound study. Ann Intensive Care 2019;9(1):50. doi:10.1186/s13613-019-0521-z.
25. Xu X, Wu R, Zhang YJ, et al. Value of Combination of Heart, Lung, and Diaphragm Ultrasound in Predicting Weaning Outcome of Mechanical Ventilation. Med Sci Monit 2020;26:e924885. doi:10.12659/msm.924885.
26. Song J, Luo Q, Lai X, et al. Combined cardiac, lung, and diaphragm ultrasound for predicting weaning failure during spontaneous breathing trial. Annals of Intensive Care 2024;14(1):60. doi:10.1186/s13613-024-0129 4-2.