Tác dụng bảo vệ gan của dung dịch uống Ích can thanh trên mô hình thực nghiệm gây viêm gan bằng ethanol

Abstract

The present study assessed the hepatoprotective effects of Ich can thanh oral solution in Swiss mice with ethanol-induced hepatitis. Mice received ethanol orally daily, with weekly increased concentrations (10%, 20%, 30%, 40%). One hour after ethanol administration, mice were given distilled water, Ich can thanh, or silymarin for four weeks. All parameters, including body weight, liver weight, blood biochemical markers (AST, ALT, GGT, albumin, and total bilirubin), liver malondialdehyde levels, glutathione concentration, and histopathological analysis, were evaluated. The results indicated that Ich can thanh at 4.8 mL/kg/day showed a trend toward hepatoprotection against ethanol-induced chronic hepatitis in mice. At 9.6 mL/kg/day, Ich can thanh significantly increased body weight, reduced liver weight, decreased serum liver enzyme levels, and attenuated oxidative stress compared to the control group. Additionally, Ich can thanh improved the histopathological features in mice with ethanol-induced chronic hepatitis. These findings suggest that Ich can thanh solution at 9.6 mL/kg/day exerts a hepatoprotective effect against ethanol-induced liver injury in experimental animals.