CYP3A5 rs776746 polymorphism and its association with blood pressure in patients with stage 3 chronic kidney disease
Main Article Content
Abstract
The rs776746 polymorphism of the CYP3A5 gene is a functional variant that affects enzyme expression and may be associated with blood pressure regulation. This cross-sectional analytical study was conducted at Thong Nhat Dong Nai General Hospital from April to December 2025 to describe genotype distribution and evaluate the association between rs776746 and blood pressure in patients with stage 3 chronic kidney disease. Among 65 patients, the frequencies of AA, AG, and GG genotypes were 15.4%, 47.7%, and 36.9%, respectively, with a G allele frequency of 60.8%. Diastolic blood pressure was significantly higher in the GG group compared with the AA/AG group. After adjustment for potential confounders, the AA/AG genotypes were associated with a 5.10 mmHg lower diastolic blood pressure compared with the GG genotype (95% CI: -8.61 to -1.58; p = 0.005). No significant association was observed between rs776746 and systolic blood pressure. These findings suggest that the rs776746 polymorphism of the CYP3A5 gene may be associated with diastolic blood pressure in patients with stage 3 chronic kidney disease.
Article Details
Keywords
rs776746 polymorphism, CYP3A5 gene, blood pressure, association
References
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