Mối liên quan giữa điểm siêu âm phổi và đáp ứng khởi trị bằng kháng sinh kinh nghiệm trong viêm phổi mắc phải cộng đồng

Abstract

Lung ultrasound (LUS) has attracted increasing attention as a bedside monitoring tool capable of assessing pulmonary lesions, thereby helping monitor treatment response in patients with community-acquired pneumonia (CAP). This prospective study included 172 patients with CAP at Cai Nuoc General Hospital and aimed to investigate the association between LUS and empiric antibiotic failure. The results showed that the shred sign and lung rockets were relatively common findings. After 72 hours of antibiotic treatment, the median total LUS score decreased from 9.0 to 7.0. The rate of empiric antibiotic failure was 11.0%. The failure group had higher LUS scores at admission and at 72 hours, with a smaller reduction in score (p < 0.001). After adjustment, the admission LUS score was independently associated with failure of empiric antibiotic therapy in both adjusted models, and the change in LUS score was independently associated with failure of empiric antibiotic therapy when adjusted for the PSI score (p < 0.05). This study suggests that LUS may be a useful adjunctive tool for assessing response to empiric antibiotic therapy in patients with community-acquired pneumonia. The admission LUS score was independently associated with treatment failure, whereas the change in LUS score after 72 hours showed suggestive value but requires further confirmation.