Polymorphism characteristics of rs1042034 in the APOB gene among patients with hypercholesterolemia and high or very high cardiovascular risk
Main Article Content
Abstract
Based on evidence regarding the association between genetic variants and blood cholesterol levels, this study investigated the relationship between the rs1042034 polymorphism of the APOB gene and blood cholesterol levels in healthy individuals and patients with high cardiovascular risk. A case–control study was conducted on 64 participants, including a healthy control group and a patient group with hypercholesterolemia at high or very high cardiovascular risk at FV Hospital from May 2025 to January 2026. The rs1042034 polymorphism genotype was determined using real-time PCR. The results showed that the frequency of the CT genotype was significantly higher in the patient group than in the control group (82.4% vs 17.6%; p = 0.002). There was no statistically significant difference observed between the CC and CT genotypes regarding systolic blood pressure, BMI, total cholesterol, triglycerides, and HDL-C levels. However, LDL-C levels differed significantly between the two genotypes (p = 0.045). The CT genotype of the APOB rs1042034 polymorphism may be associated with elevated LDL-C levels, suggesting a potential increase in the risk of atherosclerotic cardiovascular disease.
Article Details
Keywords
rs1042034, APOB gene, hypercholesterolemia, high cardiovascular risk, very high cardiovascular risk
References
2. Abdulfattah SY, Al-Awadi SJ. ApoB gene polymorphism (rs676210) and its pharmacogenetics impact on atorvastatin response among Iraqi population with coronary artery disease. J Genet Eng Biotechnol. 2021;19(1):95. doi:10.1186/s43141-021-00193-4.
3. Zhang FH, Yin RX, Yao LM, et al. Correlation between the APOB rs1042034 SNP and blood lipid characteristics of 2 ethnic groups in China. Clin Appl Thromb Hemost. 2019;25:1076029619892088. doi:10.1177/1076029619892088.
4. Ludwig EH, Blackhart BD, Pierotti VR, et al. DNA sequence of the human apolipoprotein B gene. DNA. 1987;6(4):363-372. doi:10.1089/dna.1987.6.363.
5. Fahed AC, Nemer GM. Familial hypercholesterolemia: the lipids or the genes?. Nutr Metab (Lond). 2011;8(1):23. Published 2011 Apr 22. doi:10.1186/1743-7075-8-23
6. Xiao R, Sun S, Zhang J, et al. Association analysis of APO gene polymorphisms with ischemic stroke risk: a case-control study in a Chinese Han population. Oncotarget. 2017;8(36):60496-60503. doi:10.18632/oncotarget.15549.
7. Hội Tim mạch học Việt Nam. Khuyến cáo chẩn đoán và điều trị rối loạn lipid máu. 2024.
8. Zhou F, Guo T, Zhou L, et al. Variants in the APOB gene were associated with ischemic stroke susceptibility in Chinese Han male population. Oncotarget. 2018;9(2):2249-2254. doi:10.18632/oncotarget.23369.
9. Gu QL, Han Y, Lan YM, et al. Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population. Braz J Med Biol Res. 2017;50(11):e6613. doi:10.1590/1414-431X20176613.
10. Aceves-Ramírez M, Valle Y, Casillas-Muñoz F, et al. Analysis of the APOB gene and apolipoprotein B serum levels in a Mexican population with acute coronary syndrome: association with the single nucleotide variants rs1469513, rs673548, rs676210, and rs1042034. Genet Res (Camb). 2022;2022:4901090. doi:10.1155/2022/4901090.
11. Wang YE, Kirschke CP, Woodhouse LR, et al. SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults. BMC Nutr. 2022;8(1):95. doi:10.1186/s40795-022-00592-x.