Prevalence and factors associated with Trichomonas vaginalis infection among women attending gynecologic care at Cam My Medical Center, 2025 – 2026

Nguyen Thi Kim Ha, Vu Dang Khoa, Nguyen Thi Thu, Tran Khanh Nga

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Abstract

Trichomonas vaginalis is a common cause of genital tract infection. This cross-sectional study included 263 females receiving gynecological care at Cam My Medical Center from June 2025 to January 2026, aiming to determine the prevalence and associated factors of Trichomonas vaginalis infection. The prevalence of Trichomonas vaginalis infection was 7.6%. Multivariable analysis identified vaginal douching (adjusted odds ratio [aOR] = 35.8; 95% confidence interval [CI]: 8.51 – 151.18; p < 0.001), lack of genital hygiene after sexual intercourse (aOR = 9.58; 95% CI: 2.19 – 41.84; p = 0.003), cervicitis (aOR = 9.44; 95% CI: 1.63 – 54.60; p = 0.012), and elevated vaginal leukocytes on microscopy (3+) (aOR = 3.89; 95% CI: 1.03 – 14.70; p = 0.045) as independent factors associated with Trichomonas vaginalis infection. In contrast, yellow-green frothy vaginal discharge and HIV infection were not significantly associated in the multivariable model. In conclusion, the prevalence of Trichomonas vaginalis infection was 7.6% among women receiving gynecological care. Behavioral, clinical, and laboratory factors, particularly vaginal douching, inadequate post-coital hygiene, cervicitis, and high vaginal leukocyte counts, were independently associated with infection, providing useful guidance for targeted microbiological testing.

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References

1. Kissinger PJ, Gaydos CA, Seña AC, et al. Diagnosis and Management of Trichomonas vaginalis: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines. Clinical Infectious Diseases. 2022;74(Supplement_2):S152-S161. doi:10.1093/cid/ciac030
2. Meites E, Gaydos CA, Hobbs MM, et al. A Review of Evidence-Based Care of Symptomatic Trichomoniasis and Asymptomatic Trichomonas vaginalis Infections. Clinical Infectious Diseases. 2015;61(suppl_8):S837-S848. doi:10.1093/cid/civ738
3. Wei X, Liu L, Liu K, et al. Global burden of trichomoniasis: current status, trends, and projections (1990–2021). Frontiers in Public Health. 2025;Volume 13 - 2025doi:10.3389/fpubh.2025.1530227
4. Tian W, Li Y, Zhang Y, et al. Systematic review and meta-analysis of the global prevalence and infection risk factors of Trichomonas vaginalis. Parasite (Paris, France). 2025;32:56. doi:10.1051/parasite/2025051
5. World Health Organization. Sexually transmitted infections (STIs). 2024.
6. Nguyễn Thu Hoài, Phạm Bá Nha, Trần Thị Thu Hà, và cs. Tỷ lệ nhiễm vi khuẩn lây bệnh qua đường tình dục ở phụ nữ khám phụ khoa và liên quan giữa xét nghiệm với triệu chứng lâm sàng. Tạp chí Phụ sản. 2024;22(4):78-82. doi:10.46755/vjog.2024.4.1753
7. Sethi S, Kanaujia R, Yadav R, et al. Association of intermediate Nugent Score and bacterial vaginosis with sexually transmitted infections and vulvovaginal candidiasis. Indian Journal of Dermatology, Venereology and Leprology. 2024;90doi:10.25259/IJDVL_775_2022
8. Ton Nu PA, Nguyen VQ, Cao NT, et al. Prevalence of Trichomonas vaginalis infection in symptomatic and asymptomatic women in Central Vietnam. J Infect Dev Ctries. 2015;9(6):655-60. doi:10.3855/jidc.7190
9. Phạm Mỹ Hoài, Hồ Hải Linh, Hoàng Thị Hường, và cs. Thực trạng và kết quả điều trị nhiễm trùng đường sinh dục dưới ở bệnh nhân đến khám phụ khoa tại Bệnh viện Trường Đại học Y Dược Thái Nguyên. Tạp chí Y học Việt Nam. 2022;514(2):64-69. doi:10.51298/vmj.v514i2.2596
10. Martino JL, Vermund SH. Vaginal douching: evidence for risks or benefits to women’s health. Epidemiol Rev. 2002;24(2):109-24. doi:10.1093/epirev/mxf004
11. Gafos M, Pool R, Mzimela MA, et al. The implications of post-coital intravaginal cleansing for the introduction of vaginal microbicides in South Africa. AIDS Behav. 2014;18(2):297-310. doi:10.1007/s10461-013-0676-9
12. Bouchemal K, Bories C, Loiseau PM. Strategies for Prevention and Treatment of Trichomonas vaginalis Infections. Clin Microbiol Rev. 2017;30(3):811-825. doi:10.1128/cmr.00109-16
13. Yang Y, Qu Y, Yan B, et al. The prevalence trends of Trichomonas vaginalis infection among women in Jingzhou, central of China, 2019–2023. BMC Infectious Diseases. 2025;25(1):435. doi:10.1186/s12879-025-10815-8
14. Lazenby GB, Soper DE, Nolte FS. Correlation of leukorrhea and Trichomonas vaginalis infection. J Clin Microbiol. 2013;51(7):2323-7. doi:10.1128/jcm.00416-13
15. Kirkoyun Uysal H, Koksal MO, Sarsar K, et al. Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium among Patients with Urogenital Symptoms in Istanbul. Healthcare (Basel). 2023;11(7)doi:10.3390/healthcare11070930