Đặc điểm của 18F-FDG PET/CT trong phát hiện tổn thương tái phát ở bệnh nhân ung thư biểu mô vảy cổ tử cung đã điều trị triệt căn

Abstract

This study aimed to describe the imaging characteristics and evaluate the diagnostic performance of ¹⁸F-FDG PET/CT in detecting suspected recurrent lesions in patients with cervical squamous cell carcinoma after definitive treatment. A descriptive study combining both prospective and retrospective approaches was conducted on 67 patients with clinical and/or paraclinical suspicion of recurrence who underwent ¹⁸F-FDG PET/CT at K Hospital. A total of 85 suspected recurrent lesions were identified, of which 41 were confirmed by histopathology, while the remaining lesions were verified through clinical follow-up, imaging findings, and tumor marker (SCC-Ag) monitoring for at least six months. The diagnostic performance of ¹⁸F-FDG PET/CT showed a sensitivity of 96.43%, specificity of 77.78%, and overall accuracy of 93.14% for detecting recurrence. The area under the ROC curve (AUC) was 0.87. The positive likelihood ratio (LR+) was 4.34 (95% CI: 1.85 – 10.13) and the negative likelihood ratio (LR−) was 0.05 (95% CI: 0.02 – 0.14). These findings indicate that ¹⁸F-FDG PET/CT is an effective imaging modality for detecting recurrence in patients with cervical cancer after definitive treatment and may assist in guiding subsequent management and follow-up.