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Published: 2026-05-06
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DOI: https://doi.org/10.52852/tcncyh.v201i4.5002
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Vol. 201 No. 4 (2026)
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Quyền, H. V., An, T. V., & Nga, P. T. N. (2026). Characteristics and prognostic value of ACE I/D gene polymorphism in patients with acute myocardial infarction. Journal of Medical Research, 201(4), 34-42. https://doi.org/10.52852/tcncyh.v201i4.5002

Characteristics and prognostic value of ACE I/D gene polymorphism in patients with acute myocardial infarction

Huynh Van Quyen, Tran Viet An, Pham Thi Ngoc Nga

Main Article Content

Abstract

The ACE I/D gene polymorphism plays an important role in regulating the renin–angiotensin–aldosterone system and may influence the prognosis of acute myocardial infarction. This cross-sectional descriptive study included 72 patients with acute myocardial infarction admitted to Binh Thuan General Hospital between June 2025 and January 2026. ACE I/D gene polymorphism was determined using real-time polymerase chain reaction (real-time PCR). Results showed that the ID genotype was the most prevalent (44.4%), while the DD and II genotypes accounted for 22.2% and 33.4%, respectively. After three months of follow-up, there were 19 deaths (26.4%) and 53 survivors (73.6%). The highest mortality rate was observed in patients with the DD genotype (52.6%), followed by those with the ID genotype (36.8%), and the lowest in those with the II genotype (10.6%); this difference was statistically significant (p = 0.001). The DD genotype was associated with a higher risk of all-cause mortality within three months. These findings suggest the potential application of ACE I/D gene polymorphism as a genetic biomarker for cardiovascular risk stratification in the future.

Article Details

Keywords

ACE I/D gene polymorphism, acute myocardial infarction, all-cause mortality, angiotensin II, renin–angiotensin–aldosterone system

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