Nghiên cứu độc tính cấp và độc tính bán trường diễn của viên nang cứng Gout Care trên chuột nhắt trắng

Abstract

Gout Care hard capsules are formulated from herbal ingredients including Radix Gentianae praeparata, Rhizoma et Radix Notopterygii praeparata, Radix Saposhnikoviae divaricatae praeparata, Rhizoma Gastrodiae elatae praeparata, Radix Angelicae pubescentis praeparata, and Rhizoma Ligustici wallichii praeparata. This study aimed to evaluate the acute and subchronic toxicity of the product in Swiss mice. In the acute toxicity test, mice were administered increasing doses of the capsules to determine the maximum non-lethal dose and the minimum lethal dose. The results showed that mice administered the maximum feasible oral dose (50 capsules/kg) exhibited no sign of acute toxicity and no mortality was observed. In the 28-day subchronic toxicity study, mice were divided into a control group and two treatment groups receiving 0.96 and 2.88 capsules/kg/day. After 4 weeks, general condition, body weight, hematological and biochemical indices, gross organ examination, and histopathology of liver and kidney showed no abnormal finding. In conclusion, Gout Care hard capsules did not induce acute or subchronic toxicity in Swiss mice at the tested doses.