Prevalence of Human Papillomavirus types in Nasopharyngeal carcinoma
Main Article Content
Abstract
Nasopharyngeal carcinoma (NPC) is one of 10 commonly occured cancers in Southern East of Asia, including Vietnam (3.3/100 000 individuals). Human Papillomavirus (HPV) is related to many kinds of human cancers. In this study, we investigated the association between HPV and high risk NPC. We screened HPV and detected HPV genotype in collected 99 NPC samples by Nested-PCR method with original and modified GP5+/6+ set primers. Then HPV was genotyped by direct sequencing method. Our data detected 15/99 (15.15%) HPV positive. Among them, we found 2 high-risk HPV type, including 13/15 (86.67%) HPV 16 and 2/15 (13.33%) HPV 18. Prevalent of HPV in NPC classification type III and type (I & II) were 73.33% and 26.67%, respectively. Our data suggested useful information to support disease diagnosis and treatment regimen according to NPC in the Vietnamese population.
Article Details
Keywords
Nasopharyngeal carcinoma, Human Papilomavirus, HPV 16&18
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