Preliminary characterization of the SLC30A8 rs13266634 polymorphism and its association with glycemic parameters in patients with diabetes mellitus
Main Article Content
Abstract
Genetic evidence from different populations suggests that the SLC30A8 rs13266634 polymorphism may be associated with disease susceptibility and glycemic control characteristics in patients with diabetes mellitus. However, data from Vietnam remain limited. We conducted a descriptive cross-sectional study on 90 patients with diabetes mellitus at Le Van Thinh Hospital between September 2025 and January 2026. The CT genotype was the most frequent, accounting for 65.6%, followed by CC (26.7%) and TT (7.8%); the frequencies of the C and T alleles were 59.4% and 40.6%, respectively. Fasting plasma glucose and HbA1c differed significantly across genotype groups (p < 0.05). In multivariable linear regression adjusted for age, body mass index, smoking status, insulin use, and number of oral antidiabetic agents, each additional T allele was associated with a mean increase of 23.86 mg/dL in fasting plasma glucose and 0.45% in HbA1c. These preliminary findings suggest that the SLC30A8 rs13266634 polymorphism may be associated with fasting plasma glucose and HbA1c in Vietnamese patients with diabetes mellitus.
Article Details
Keywords
rs13266634 polymorphism, SLC30A8 gene, glycemic parameters, association
References
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