Value of the CLIF-C ACLF score in predicting treatment outcomes in patients with acute-on-chronic liver failure
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Abstract
A prospective cohort study of 132 patients with acutely decompensated cirrhosis treated at Binh Thuan General Hospital from June 2025 to January 2026 found that the prevalence of acute-on-chronic liver failure was 44.7%, with no in-hospital death recorded. Compared with patients without ACLF, those with ACLF had significantly higher total bilirubin, creatinine, potassium, AST, ALT, INR, CLIF-C OF scores, and CLIF-C ACLF scores, whereas sodium and albumin levels were significantly lower. Among patients with ACLF, those who did not improve after treatment had higher white blood cell counts, INR, CLIF-C OF scores, and CLIF-C ACLF scores, together with lower albumin levels compared to those who improved. The CLIF-C ACLF score showed predictive value for non-improvement after treatment, with an optimal cutoff of 58, a sensitivity of 83.3% and a specificity of 68.3%. These findings suggest that the CLIF-C ACLF score may help identify patients with ACLF at higher risk of poor treatment response, thereby supporting risk stratification and guiding appropriate monitoring and management in clinical practice.
Article Details
Keywords
acute-on-chronic liver failure, CLIF-C ACLF score, cirrhosis, prognosis, treatment outcome
References
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