Đa hình rs1333049 gen ANRIL và một số yếu tố nguy cơ tim mạch ở bệnh nhân nghi ngờ bệnh động mạch vành: Nghiên cứu thăm dò

Abstract

The rs1333049 polymorphism of the ANRIL gene has been reported to be associated with coronary artery disease (CAD) risk; however, data in Vietnam remain limited. This cross-sectional descriptive study was conducted on 44 patients with suspected coronary artery disease who underwent coronary angiography, aiming to investigate the distribution of the rs1333049 polymorphism of the ANRIL gene and selected cardiovascular risk factors. The mean age of the study population was 68.84 ± 7.76 years old, with females accounting for 56.8%. Hypertension was the most prevalent risk factor (97.7%). The genotype frequencies of rs1333049 (ANRIL) CC, CG, and GG were 40.9%, 47.7%, and 11.4%, respectively. The allele frequencies of C and G were 64.8% and 35.2%, respectively. A statistically significant difference was observed in the prevalence of type 2 diabetes mellitus among rs1333049 genotypes (p = 0.038). However, no significant association was found between the rs1333049 polymorphism and coronary artery stenosis (p > 0.05). Conclusion: This preliminary study suggests a potential association between the rs1333049 polymorphism of the ANRIL gene and type 2 diabetes mellitus; however, the evidence remains insufficient to confirm this association. No significant association between the rs1333049 polymorphism and significant coronary artery stenosis was observed in this study population.