Đáp ứng điều trị ung thư dạ dày tân bổ trợ bằng phác đồ flot

Abstract

The objective of the study was to describe the histopathological and endoscopic characteristics of operable locally advanced gastric cancer and evaluate the response to neoadjuvant chemotherapy of gastric cancer with FLOT at Hanoi Medical University Hospital. A descriptive study of a series of diseases was performed on 29 patients with locally advanced gastric cancer in the region with surgical ability (difficult prognosis) who were treated with neo-adjuvant chemotherapy FLOT at the Department of Oncology and Palliative Care - Hanoi Medical University Hospital from August 2018 to June 2021. Median age was 60 (30 - 72). The male/female ratio was 3.14/1. Overall status ECOG 0.1 accounted for 96.6%. The main reason for admission was epigastric pain, accounting for 69%. The most common symptom was abdominal pain accounting for 82.8%; black stools accounted for 17.2%; Vomiting, nausea accounted for 34.5%; The most common tumor location was the pyloric with 55.2%, followed by the cardia (31%). Ulcer type was the most common form, accounting for 41%, and mixed form of ulceration accounts for 38%. Evaluation of patients before treatment: 100% cT3-4, 96.6% had metastatic lymph nodes. The percentage of patients with clinical-symptom improvement was 96,6%. The rate of patients undergoing surgery was 82.6%, no patient progressed during the treatment period. One patient died from surgical complications. Histopathologically, the rate of complete response, partial response and unchanged was 10.3%, 51.7% and 38%, respectively; The ratio of cross section R0 reached 91.7%.