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Published: 2026-07-06
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DOI: https://doi.org/10.52852/tcncyh.v203i6.5262
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Vol. 203 No. 6 (2026)
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Phương, T. T. T., & Thủy, N. T. P. (2026). The association between hyperuricemia, generalized pain, and functional disability in patients with gout. Journal of Medical Research, 203(6), 182-190. https://doi.org/10.52852/tcncyh.v203i6.5262

The association between hyperuricemia, generalized pain, and functional disability in patients with gout

Tran Thi Thu Phuong, Nguyen Thi Phuong Thuy

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Abstract

A cross-sectional descriptive study was conducted on 81 patients with acute and chronic gout diagnosed according to the 2015 ACR/EULAR criteria at the Rheumatology Center, Bach Mai Hospital, from October 2025 to April 2026. The mean age was 53.7 ± 15.3 years old; with 91.4 male patients. The median functional disability index was 0.875 (IQR: 0.375 – 1.25). Generalized pain hypersensitivity, assessed using the Generalized Pain Questionnaire (GPQ), was identified in 24.7% of patients (20/81). The most common symptoms in this group included pain from light touch (100%), pain from friction on skin (95%), pain that lasts longer compared with most other people (100%), and unusually intense experiences of pain (100%). Multivariate logistic regression analysis demonstrated excellent predictive performance (AUC = 0.943; p < 0.001; 95% CI: 0.892 – 0.995). Joint pain severity measured by VAS and serum uric acid levels were independent predictors of generalized pain hypersensitivity, with VAS score showing the strongest association (p = 0.006; OR = 8.132; 95% CI: 1.818 – 36.37).

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Keywords

Gout, generalized pain, Generalized Pain Questionnaire

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