The clinical value of several reticulocyte indice
Main Article Content
Abstract
Reticulocytes are immature red blood cells. Reticulocytes originate in the bone marrow and undergo further diferentiation into mature red blood cells. Then, they are released into the peripheral. The enumeration of peripheral blood reticulocytes (“reticulocyte counting”) and rate of reticulocyte are often performed to obtain information about the function of the erythropoiesis. Reticulocyte enumeration is also valued in monitoring bone marrow regenerative activity after chemotherapy or bone marrow transplantation. Currently, the new techniques provide a variety of reticulocyte-related parameters, such as reticulocyte hemoglobin content (CHr), Immature reticulocyte fraction (IRF), reticulocyte hemoglobin (retHb), reticulocyte maturation index (RMI). These parameters are under evaluation in the clinical diagnosis and monitoring of hematologic pathology.
Article Details
Keywords
Reticulocytes, Anemia
References
2. Mescher, A. L.Junqueira’s basic histology: text and atlas. New York: McGraw-Hill Medical. 2013; 13th ed., vol. 12.
3. Vchynnikova, E., Aglialoro, F., Bentlage & et. DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism. Blood, The Journal of the American Society of Hematology., vol. 130, no. 12, 2017; pp. 1441-1444.
4. Chasis, J. A., Prenant & et. Membrane assembly and remodeling during reticulocyte maturation. 1989; pp. 1112-1120.
5 Bessman, J. D. Clinical Methods: The History, Physical, and Laboratory Examinations. 1990; 3rd edition.
6 Marković, Majkić-Singh, Ignjatović & et. Reticulocyte haemoglobin content vs. soluble transferrin receptor and ferritin index in iron deficiency anaemia accompanied with inflammation. 2007; International journal of laboratory hematology., vol. 29, no. 5, pp. 341-346.
7. Vázquez-López, M. A., López-Ruzafa & et. The usefulness of reticulocyte haemoglobin content, serum transferrin receptor and the sTfR-ferritin index to identify iron deficiency in healthy children aged 1-16 years. European journal of pediatrics., vol. 178, no. 1, 2019; pp. 41-49.
8. Nalado, A. M., Mahlangu & et. Utility of reticulocyte haemoglobin content and percentage hypochromic red cells as markers of iron deficiency anaemia among black CKD patients in South Africa. PloS one., vol. 13, no. 10, 2018; pp. e0204899.
9. Brugnara, C., Zelmanovic, D. & et. Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity. American journal of clinical pathology., vol. 108, 1997; no. 2, pp. 133-142.
10. Davis, B. H., Ornvold & et. Flow cytometric reticulocyte maturity index: a useful laboratory parameter of erythropoietic activity in anemia. Cytometry: The Journal of the International Society for Analytical Cytology, vol. 22, 1995; no. 1, pp. 35-39.
11. Davis, B. H., Bigelow & et. Flow cytometric reticulocyte analysis and the reticulocyte maturity index. Annals of the New York Academy of Sciences, vol. 677, 1993; pp. 281-292.
12. https://www.sysmex.ch/ch-fr/academie/centre-dexpertise/scientific-kalender/messtechnologien-und-scattergramme.html.
13. Chang, C. C., Kass & et. Clinical significance of immature reticulocyte fraction determined by automated reticulocyte counting. American journal of clinical pathology, vol. 108, 1997; no. 1, pp. 69-73.
14. Conley, C. L., Lippman & et. Autoimmune hemolytic anemia with reticulocytopenia and erythroid marrow. New England Journal of Medicine., vol. 306, no. 5, 1982; pp. 281-286.
15. Hertenstein, B., Kurrle & et. Pseudoreticulocytosis in a patient with myelodysplasia. Annals of hematology, vol. 67, no. 3, 1993; pp. 127-128.
16. Sowade, O., Sowade & et. Kinetics of reticulocyte maturity fractions and indices and iron status during therapy with epoetin beta (recombinant human erythropoietin) in cardiac surgery patients. American journal of hematology, vol. 55, no. 2, 1997; pp. 89-96.
17. Schaefer, R. M., Schaefer & et. Hypochromic red blood cells and reticulocytes. Kidney International, vol. 55, 1999; pp. S44-S48
18. Mast, A. E., Blinder & et. Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency. Blood, The Journal of the American Society of Hematology, vol. 99, no. 4, 2002; pp. 1489-1491.
19. Fishbane, S., Galgano & et. Reticulocyte hemoglobin content in the evaluation of iron status of hemodialysis patients. Kidney international, vol. 52, no. 1, 1997; pp. 217-222.
20. Chang, C. C., Kass & et. Clinical significance of immature reticulocyte fraction determined by automated reticulocyte counting. American journal of clinical pathology, vol. 108, no. 1, 1997; pp. 69-73.