Early outcomes of radical inferior mesenteric artery lymphadenectomy with left colic artery preservation in upper rectal cancer

Chu Quoc Hoan, Duong Chi Thanh, Nguyen Xuan Dai, Nguyen Van Hieu

Main Article Content

Abstract

This descriptive study included 140 patients with upper rectal cancer who underwent inferior mesenteric root lymphadenectomy with left colic artery preservation at K Hospital (July 2017 - December 2025) to evaluate safety and early oncological outcomes. The mean age was 62.4 ± 11.0 years old, males represented 52.1%. Preoperatively, cT3-4 disease, clinically positive nodes, and stage III disease accounted for 87.9%, 66.4%, and 66.4%, respectively; 31.4% of patients received neoadjuvant treatment. The mean operative time was 110.5 ± 19.2 minutes and the mean hospital stay was 7.43 ± 0.83 days. The 30-day complication rate was 2.1%, with no instance of anastomotic leakage, reoperation, or mortality. The mean lymph node yield was 14.80 ± 5.83 (significantly higher in the upfront surgery group, p = 0.0496), pathological node positivity was 35.7%, and the positive circumferential resection margin (CRM) was 0.7%. Among neoadjuvant-treated patients, the pathological complete response (pCR) rate reached 20.5% and TNM downstaging was 72.7%. This procedure demonstrated high safety, adequate nodal assessment, and meaningful pathological response.

Article Details

References

1. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024; 74(3): 229-263. doi:10.3322/caac.21834.
2. Benson AB, Venook AP, Adam M, et al. NCCN guidelines insights: rectal cancer, version 3.2024. J Natl Compr Canc Netw. 2024; 22(6): 366-375. doi:10.6004/jnccn.2024.0041.
3. Benson AB, Venook AP, Al-Hawary MM, et al. Rectal cancer, version 6.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2020; 18(7): 806-815. doi:10.6004/jnccn.2020.0032.
4. You YN, Hardiman KM, Bafford A, et al. The American Society of Colon and Rectal Surgeons clinical practice guidelines for the management of rectal cancer. Dis Colon Rectum. 2020; 63(9): 1191-1222. doi:10.1097/DCR.0000000000001762.
5. Kinugasa Y, Uehara K, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2024 for the treatment of colorectal cancer. Int J Clin Oncol. Published online 2025. doi:10.1007/s10147-025-02899-8.
6. Fan YC, Ning FL, Zhang CD, Dai DQ. Preservation versus non-preservation of left colic artery in sigmoid and rectal cancer surgery: a meta-analysis. Int J Surg. 2018; 52: 269-277. doi:10.1016/j.ijsu.2018.02.054.
7. Hajibandeh S, Hajibandeh S, Maw A. Meta-analysis and trial sequential analysis of randomized controlled trials comparing high and low ligation of the inferior mesenteric artery in rectal cancer surgery. Dis Colon Rectum. 2020; 63(7): 988-999. doi:10.1097/DCR.0000000000001693.
8. Yin TC, Chen YC, Su WC, et al. Low ligation plus high dissection versus high ligation of the inferior mesenteric artery in sigmoid colon and rectal cancer surgery: a meta-analysis. Front Oncol. 2021; 11: 774782. doi:10.3389/fonc.2021.774782.
9. Huang X, Xiao Z, Huang Z, et al. Laparoscopic D3 lymph node dissection with left colic artery and first sigmoid artery preservation in rectal cancer. World J Surg Oncol. 2023; 21(1): 77. doi:10.1186/s12957-023-02964-4.
10. Quách Văn Kiên. Nghiên cứu ứng dụng phẫu thuật nội soi bảo tồn cơ thắt trong ung thư trực tràng giữa và dưới. Luận án Tiến sĩ, Trường Đại học Y Hà Nội; 2019.
11. Lykke J, Jess P, Roikjaer O, Danish Colorectal Cancer Group. A minimum yield of twelve lymph nodes in rectal cancer remains valid in the era of neo-adjuvant treatment: results from a national cohort study. Int J Colorectal Dis. 2015; 30(3): 347-351. doi:10.1007/s00384-015-2145-6.
12. Yu L, Wang L, Tan Y, et al. Accuracy of magnetic resonance imaging in staging rectal cancer with multidisciplinary team: a single-center experience. J Cancer. 2019; 10(26): 6594-6598. doi:10.7150/jca.32685.
13. Martin ST, Heneghan HM, Winter DC. Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer. Br J Surg. 2012; 99(7): 918-928. doi:10.1002/bjs.8702.