Article Sidebar

PDF (Tiếng Việt)
Published: 2021-12-01
Abstract Views: 298
Views PDF (Tiếng Việt): 254
DOI: https://doi.org/10.52852/tcncyh.v147i11.538
Issue
Vol. 147 No. 11 (2021)
Section
Các bài báo
How to Cite
Hoa, T. T. ., Luận, Đào T. ., Dũng, T. N., & Quỳnh, N. T. . (2021). Colorectal adenomacarcinoma in a patient with peutz-jeghers syndrome. Journal of Medical Research, 147(11), 296-301. https://doi.org/10.52852/tcncyh.v147i11.538

Colorectal adenomacarcinoma in a patient with peutz-jeghers syndrome

Hoa1, Đào Thị Luận, Trần Ngọc Dũng, Nguyễn Thị Quỳnh
1 Đại học y Hà Nội

Main Article Content

Abstract

Peutz-Jeghers Syndrome (PJS) is a rare disease, characterized by hamartomatous polyposis of the gastro-intestinal (GI) tract and pigmentation around lips, eyelids and macules on the buccal mucosa. The objective of the study was to describe one case of colorectal adenocarcinoma in a patient with Peutz-Jeghers Syndrome. A case study report was applied. A 36-year-old male with PJS was hospitalized because of vomiting and intermittent abdominal pain. Imaging showed small-bowel intussusception in the pelvic region, along with colorectal polyps; the largest polyp in the high rectum measuring 38 x 37 mm was lobulated. Pathological results showed that the large polyp in the rectum is adenocarcinoma invading the smooth muscle layer; other polyps are typical Peutz-Jeghers polyps, with low-grade dysplasia. The patient was diagnosed with a moderately differentiated adenocarcinoma invading the smooth muscle layer/ Peutz-Jeghers syndrome.

Article Details

Keywords

Peutz-Jeghers Syndrome, colorectal adenocarcinoma.

References

1. Islam M.R., Hossain M.S, Sheikh M.S., et al (2015). Peutz-Jeghers syndrome: a case report and literature review. Journal of Dhaka Medical College. 23(1).
2. Homan M., Dolenc Strazar, et al (2005). Peutz-Jeghers syndrome. A case report. Acta Dermatovenerol Alp Panonica Adriat. 14(1), 26-29.
3. Finan et al (1989). Gastrointestinal Polyposis Syndromes. Dermatologic Clinics. 7(3), 419-434.
4. Pereira C.M., Coletta R.D., Jorge J., et al (2005). Peutz-Jeghers syndrome in a 14-year-old boy: case report and review of the literature. Int J Paediatr Dent. 15(3), 224-8.
5. Fernandez M.J., Martinez M.I., Fernandez J.R., et al (1995). Peutz-Jeghers syndrome in a neonate. J Pediatr. 126 (6), 965-7.
6. Hinds R., Philp C., Hyer W., et al (2004). Complications of childhood Peutz-Jeghers syndrome: implications for pediatric screening. J Pediatr Gastroenterol Nutr. 39 (2), 219-20.
7. Spigelman A.D., Thomson J.P. and Phillips R.K. (1990). Towards decreasing the relaparatomy rate in the Peutz–Jeghers syndrome: the role of preoperative small bowel endoscopy. Br J Surg. 77(3), 301–302.
8. Boardman L.A, Couch F.J, Burgart L.J, et al (2000). Genetic heterogeneity in Peutz-Jeghers syndrome. Hum Mutant 2000. 16, 23-30.
9. Hearle N., Schumacher V., Menko F.H., et al (2006). Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res. 12, 3209–3215.
10. Giardiello F.M., Brensinger J.D., Tersmette A.C., et al (2000). Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology. 119, 1447–1453.
11. Beggs A.D., Latchford A.R., Vasen H.F., et al (2010). Peutz-Jeghers syndrome: a systematic review and recommendations for management. Gut. 59(7), 975-86.
12. McGarrity T.J., Amos C. (2006). Peutz-Jeghers syndrome: clinicopathology and molecular alterations. Cell. Mol. Life Sci. 63, 2135-2144.
13. Hyun-Dong Chae., Chang-Ho Jeon (2014. Peutx-Jeghers syndrome with germline mutation of STK11. Ann Surg Treat Res. 86(6), 325-330.