Nghiên cứu tác dụng của dung dịch điện giải ion kiềm ECO G9 lên chỉ số lipid máu và acid uric máu trên mô hình động vật thực nghiệm

Abstract

 This study assessed the ameliorating effects of the ECO G9 alkaline-electrolyzed water (ECO
G9) in experimental animals with dyslipidemia and hyperuricemia. Anti-hyperlipoproteinemia
by endogenous hyperlipidemia were induced in mice by administration of intraperitoneal (i.p.)
injection of Poloxamer-407 (200 mg/kg). In the exogenous dyslipidemia model, rats were given oral
administration of oil-cholesterol mixture for 4 consecutive weeks. Mice blood samples were collected
to measure the concentrations of TG, TC, HDL-C, LDL-C, non-HDL-C, and AST, ALT. On day 5,
after 1 hour of oral ECO G9, mice were injected intraperitoneally with potassium oxonate at a dose
of 500 mg/kg. After 2 hours of injection, carotid blood samples were taken to quantify serum uric
acid levels. The results showed that ECO G9 at two doses, 160 mL/kg and 240 mL/kg, significantly
reduced level of TG and non-HDL-C but did not change the level of HDL-C. In the exogenous
dyslipidemia model, ECO G9 at 80 mL/kg showed potential to control dyslipidemia by significantly
decreasing TG level (p < 0.05), and ECO G9 at 120 mL/kg did not change the level of HDL-C.
Both does levels did not have any significantly effect on blood lipid parameters and liver enzyme
levels. Additionally, ECO G9 at both 160 mL/kg/day and 240mL/kg/day reduced blood uric acid.