Các yếu tố liên quan đến kiểm soát bệnh ở bệnh nhân mày đay mạn tính tự phát đáp ứng không hoàn toàn với kháng Histamin H1 liều cao

Abstract

An ambispective study was conducted on 250 patients with chronic spontaneous urticaria (CSU) who failed to achieve complete disease control after 4 weeks of treatment with maximum-dose (up to fourfold standard dose) of the second-generation H1 antihistamines (sgAH1s Factors associated with poor disease control (UCT < 12) were investigated. The results showed that the rate of poor disease control among CSU patients who did not achieve complete control with fourfold-dose sgAH1s was 53.6%. Compared with the well-controlled group, patients with poor disease control under high-dose sgAH1 therapy were older, had higher baseline UAS7 scores, and lower total IgE levels (p < 0.05). Multivariable logistic regression analysis demonstrated that low total IgE levels (OR = 4.54; p = 0.02) and higher baseline UAS7 scores (OR = 1.04; p = 0.03) were independently associated with poor disease control among CSU patients who failed to achieve complete control with high-dose sgAH1. The model demonstrated modest discrimination (AUC = 0.668). Identification of these factors may help recognize CSU patients who are more likely to experience suboptimal disease control with high-dose sgAH1 therapy and may provide additional clinical context for future studies on individualized management strategies.