The milan score in high-resolution esophageal manometry among patients with reflux symptoms
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Abstract
To evaluate the Milan score and associated factors in patients with reflux symptoms, a cross-sectional study was conducted on 141 patients aged ≥ 18 years old with reflux symptoms (GerdQ score ≥ 8); patients were enrolled as they underwent high-resolution esophageal manometry (HRM) and upper gastrointestinal endoscopy at The Institute of Gastroenterology and Hepatology and Hoang Long Clinic between December 10, 2025 and March 31, 2026. The median Milan score of the study group was 85, with 37.6% of patients having a Milan score ≥ 137, corresponding to a high risk for Gastroesophageal Reflux Disease (GERD). In multivariable logistic regression analysis, body mass index (BMI), heartburn, symptom duration (months), and endoscopic reflux esophagitis according to the Los Angeles (LA) classification were independent factors significantly associated with a high risk of GERD based on the Milan score. Specifically, BMI (OR = 1.192; 95% CI: 1.008 – 1.411; p = 0.041), heartburn (OR = 3.255; 95% CI: 1.372 – 7.720; p = 0.007), symptom duration (OR = 1.026; 95% CI: 1.003 – 1.050; p = 0.029), and the presence of reflux esophagitis on endoscopy (OR = 3.271; 95% CI: 1.378 – 7.766; p = 0.007). The Milan score was associated with clinical characteristics and esophageal mucosal injury, which may assist to identify patients at high risk of reflux.
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Keywords
High-Resolution Esophageal Manometry (HRM), Milan score, reflux, gastroesophageal
References
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