Characteristics of red cell alloantibodies in pediatric patients with Alpha thalassemia at the National Institute of hematology and Blood transfusion, 2023–2025
Main Article Content
Abstract
Red cell alloantibodies reduce transfusion efficacy in pediatric patients with thalassemia. A cross-sectional study was conducted on 253 pediatric alpha-thalassemia patients who had complete transfusion records and red cell alloantibody test results. Antibody screening and identification were performed using column agglutination technology with red cell panels from the National Institute of Hematology and Blood Transfusion and commercial panels from Grifols. Statistical analysis was performed using SPSS software version 27.0. The prevalence of red cell alloantibodies was 8.7% (22/253 cases) where Rh system alloantibodies represented 63.34% followed by 30.0% of the MNS system; anti-E and anti-Miᵃ were the most frequently identified antibodies. The prevalence of red cell alloantibodies was significantly higher in Kinh children than in children from other ethnic groups (12.7% vs. 5.2%; p = 0.044) and increased markedly with the cumulative number of transfused packed red blood cell units (p < 0.0001).
Article Details
Keywords
Alpha-thalassemia, pediatric, red cell alloantibodies, blood transfusion
References
2. Nguyễn Thị Thu Hà, Nguyễn Triệu Vân, Ngô Mạnh Quân, et al. Tổng quan Thalassemia, thực trạng, nguy cơ, giải pháp kiểm soát bệnh Thalassemia ở Việt Nam. Tạp chí Y học Việt Nam. 2021; 502 (3-16).
3. Pradhan S, Behera BK, Prusty JBK, Satpathy S, Panda K. Red cell alloimmunization and its correlation with clinical spectrum and transfusion profile in pediatric thalassemia major patients: experience from a tertiary care pediatric center in Northern India. Indian J Hematol Blood Transfus. 2025;41:298-305.
4. Teawtrakul N, Songdej D, Hantaweepant C, et al. Red blood cell alloimmunization and other transfusion-related complications in patients with transfusion-dependent thalassemia: a multi-center study in Thailand. Transfusion. 2022;62(10):2039-2047.
5. Indriani V, Mulyono B, Triyono T, Handayaningsih AE, Chandra LA. Prevalence of alloimmunization events in thalassemia patients with repeated transfusions in the Rhesus blood group system: a systematic review and meta-analysis. J Clin Med Res. 2025;17(2):106-118.
6. Nguyen TQ, Do TT, Hoang NTT, Bach KQ, Nguyen TH. Frequencies of different blood group antigens and phenotypes in Northern Vietnamese donors. Transfus Med. 2025;35:346-351.
7. Bạch Quốc Khánh, Nguyễn Thị Thu Hà, Ngô Mạnh Quân, et al. Khảo sát tình hình mang gen bệnh Thalassemia và bệnh Huyết sắc tố ở 6 dân tộc thiểu số khu vực đông bắc bộ. Tạp chí Y học Việt Nam. 2021;502 (49-57).
8. Al-Riyami AZ, Daar S. Red cell alloimmunization in transfusion-dependent and transfusion-independent beta thalassemia: a review from the Eastern Mediterranean Region (EMRO). Transfus Apher Sci. 2019;58:102678.
9. El-Beshlawy A, Salama A, El-Masry MR, El Husseiny NM, Abdelhameed AM. A study of red blood cell alloimmunization and autoimmunization among 200 multitransfused Egyptian β thalassemia patients. Sci Rep. 2020;10:21079.
10. De Moraes-Pinto MI, Suano-Souza F, Aranda CS. Immune system: development and acquisition of immunological competence. J Pediatr (Rio J). 2021;97(suppl 1):S59-S66.
11. Singer ST, Wu V, Mignacca R, Kuypers FA, Morel P, Vichinsky EP. Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent. Blood. 2000;96(10):3369-3373.