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Published: 2026-08-25
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DOI: https://doi.org/10.52852/tcncyh.v205i8.5565
Issue
Vol. 205 No. 8 (2026)
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Các bài báo
How to Cite
Thảo, N. T. P., & Andrei Ivanovich, K. . (2026). Pregnancy-related rhinosinusitis: A narrative review of differential diagnosis and treatment safety. Journal of Medical Research, 205(8), 951-960. https://doi.org/10.52852/tcncyh.v205i8.5565

Pregnancy-related rhinosinusitis: A narrative review of differential diagnosis and treatment safety

Nguyen Thi Phuong Thao, Kryukov Andrei Ivanovich

Main Article Content

Abstract

Nasal congestion during pregnancy arises from diverse mechanisms, including pregnancy rhinitis, allergic rhinitis, and acute bacterial rhinosinusitis; distinguishing among these entities is essential for appropriate management, yet specific guidance is lacking in Vietnam. This review synthesizes evidence on predictors, efficacy, and safety of treatments for rhinosinusitis in pregnant women using a narrative review approach per SANRA, with systematic searches of PubMed, Cochrane, and Embase and quality appraisal by GRADE. Thirty-eight eligible studies were included, with evidence ranging from low to moderate. The most reliable indicators of bacterial infection were purulent nasal discharge, facial pain, reduced olfaction, and symptoms lasting more than 10 days. Saline irrigation and intranasal budesonide exhibited the most favorable safety profiles in pregnancy. Antibiotics should be reserved for cases with documented bacterial infection. Rhinosinusitis in pregnancy requires systematic assessment and stepwise management, and prospective data from Vietnam are needed to develop local clinical practice guidelines.

Article Details

Keywords

Rhinosinusitis, pregnancy, pregnancy rhinitis, intranasal corticosteroids, drug safety, differential diagnosis

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