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Published: 2022-03-01
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DOI: https://doi.org/10.52852/tcncyh.v151i3.608
Issue
Vol. 151 No. 3 (2022)
Section
Các bài báo
How to Cite
Hồng, N. T. T. ., Bảy, L. H. ., Tùng, C. V. ., & Thục, L. T. M. . (2022). Effects of preoperative carbohydrate loading on insulin resistance in children undergoing ventricular septal defect surgery at Vietnam National Children’s Hospital. Journal of Medical Research, 151(3), 73-79. https://doi.org/10.52852/tcncyh.v151i3.608

Effects of preoperative carbohydrate loading on insulin resistance in children undergoing ventricular septal defect surgery at Vietnam National Children’s Hospital

Nguyen Thi Thuy Hong, Luong Huu Bay, Cao Viet Tung, Luu Thi My Thuc

Main Article Content

Abstract

This study assessed the effectiveness of preoperative oral carbohydrate loading on insulin
resistance in patients undergoing ventricular septal defect surgery in Vietnam National Children’s
Hospital. A total of 36 patients aged 2 months to 12 months undergoing ventricular septal defect surgery
were enrolled and randomized into two treatment groups: one group received 12.5% carbohydrate
loading 2 hours and the other group were instructed to fast for 4-6 hours before surgery. The clinical
characteristics and laboratory tests were evaluated both at before and after surgery. The postoperative
glucose and insulin concentrations were lower in the intervention group than the control group. The
postoperative HOMA-IR and QUICKI significantly improved in the intervention group (p=0.007).
There was no incidence of lung aspiration in the intervention group. The results suggested that
preoperative oral carbohydrate loading was safe and effective in reducing patient’s insulin resistance.

Article Details

Keywords

carbohydrate, preoperative fasting, ventricular septal defect, HOMA, QUICKI, ERAS

References

1. Rizvanović N, Nesek Adam V, Čaušević S, et al. A randomised controlled study of preoperative oral carbohydrate loading versus fasting in patients undergoing colorectal surgery. Int J Colorectal Dis. 2019;34(9):1551-1561.
2. Bilku DK, Dennison AR, Hall TC, et al. Role of preoperative carbohydrate loading: a systematic review. Ann R Coll Surg Engl. 2014;96(1):15-22.
3. Dobson G, Chong M, Chow L, et al. Guidelines to the Practice of Anesthesia - Revised Edition 2018. Can J Anaesth J Can Anesth. 2018;65(1):76-104.
4. Doyle DJ, Garmon EH. American Society of Anesthesiologists Classification (ASA Class). In: StatPearls. StatPearls Publishing; 2020. Accessed March 30, 2020. http://www.ncbi.nlm.nih.gov/books/NBK441940.
5. Engelman DT, Ali WB, Williams JB, et al. Guidelines for Perioperative Care in Cardiac Surgery: Enhanced Recovery After Surgery Society Recommendations. JAMA Surg. 2019; 154(8):755-766.
6. Tudor-Drobjewski BA, Marhofer P, Kimberger O, et al, Triffterer L. Randomised controlled trial comparing preoperative carbohydrate loading with standard fasting in paediatric anaesthesia. Br J Anaesth. 2018; 121(3):656-661.
7. M. E. Atabek, O. Pirgon. Assessment of Insulin Sensitivity from Measurements in Fasting State and During an Oral Glucose Tolerance Test in Obese Children. J Pediatr Endocrinol Metab. 2007;20(2):187-196.
8. Smith I, Kranke P, Murat I, et al. Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 2011; 28(8):556-569.
9. Pogatschnik C, Steiger E. Review of Preoperative Carbohydrate Loading. Nutr Clin Pract. 2015;30(5):660-664.
10. Jiang W, Liu X, Liu F, et al. Safety and benefit of pre-operative oral carbohydrate in infants: a multi-center study in China. Asia Pac J Clin Nutr. 2018;27(5):975-979.
11. Savage David B., Petersen Kitt F., Shulman Gerald I. Mechanisms of Insulin Resistance in Humans and Possible Links With Inflammation. Hypertension. 2005;45(5):828833.