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Published: 2022-03-01
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DOI: https://doi.org/10.52852/tcncyh.v151i3.616
Issue
Vol. 151 No. 3 (2022)
Section
Các bài báo
How to Cite
Phượng, L. T. ., Huy, T. N. ., Huy, N. N. ., Bích, V. N. ., & Hương, N. T. . (2022). Antibiotic resistance in children with urinary tract infections and urinary tract abnormalities in Vietnam National Children’s Hospital. Journal of Medical Research, 151(3), 98-105. https://doi.org/10.52852/tcncyh.v151i3.616

Antibiotic resistance in children with urinary tract infections and urinary tract abnormalities in Vietnam National Children’s Hospital

Luong Thi Phuong, Tong Ngoc Huy, Nguyen Ngoc Huy, Vu Ngoc Bich, Nguyen Thu Huong

Main Article Content

Abstract

 Urinary tract infection (UTI) is one of the most common infections in children, second only to
respiratory and digestive infections. Urinary tract abnormalities (UTA) increase the risk of UTIs and
the incidence of antibiotic resistance, often requiring longer intravenous antibiotic therapy than
conventional UTIs. This study assessed the prevalence of antibiotic resistance among 90 children
who had both UTI caused by positive bacteriuria and urinary tract abnormalities (54.4% male and
45.6% female). The most common urinary tract abnormality was vesicoureteral reflux (VUR-72.2%),
of which 72.3% were VUR grade III - V. Common causes of UTIs were Escherichia coli (43.3%),
Klebsiella pneumoniae (17.8%), and fungi (11.1%). The majority of Escherichia coli (78.9%) and
Klebsiella pneumoniae (62.5%) produced ESBL. Escherichia coli was resistant to most β-lactam
antibiotics such as Ampicillin (97.1%), Cefotaxime (79.5%), and Quinolone (56.4%), Gentamycin
(53.8%). Escherichia coli was sensitive to Amikacin (92.3%), Fosfomycin (79.5%), Carbapenem
(71.8%). Klebsiella pneumoniae had a high rate of resistance to 3rd generation Cephalosporins
(70.6%), and was sensitive to Amikacin (82.6%), Carbapenem (75.6%), and Fosfomycin (52.9%).

Article Details

Keywords

Urinary tract infection, urinary tract abnormalities, antibiotic resistance

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