Risk factors for the development of alcohol withdrawal delirium
Main Article Content
Abstract
This study was conducted to evaluate risk factors predicting the development of alcohol withdrawal delirium; 56 patients in E hospital were divided into 2 groups of 28 patients each, diagnosed for mental and behavioral disorders due to alcohol abuse : group 1 has withdrawal state with delirium (F10.4) and group 2 has withdrawal state (F10.3) according to ICD - 10 criteria; this is a retrospective, case - control study; result showed that the duration of drinking - between 10 and 20 years (OR = 10.8; 95% CI: 1.25 - 93.4), age onset of drinking - before 30 years old (OR = 3.47; 95%CI: 1.11 - 10.75); the amount of daily alcohol intake - above 500ml (OR = 25.04; 95%CI: 5.73 - 108.91) emerged as strong predictors for alcohol withdrawal delirium. These alcohol dependence risk factors can be easily evaluated in a clinical setting to identify patients at risk for developing alcohol withdrawal delirium for physician to develop an intensive therapy plan for treatment.
Article Details
Keywords
alcohol withdrawal delirium, risk factor.
References
2. Mayo - Smith MF. Pharmacological Management of Alcohol Withdrawal: A Meta - analysis and Evidence - Based Practice Guideline. JAMA. 1997;278(2):144 - 151. doi:10.1001/jama.1997.03550020076042
3. Francis J. Delirium in Older Patients. J Am Geriatr Soc. 1992;40(8):829 - 838. doi:10.1111/j.1532 - 5415.1992.tb01859.x
4. Management of Withdrawal Delirium (Delirium Tremens). N Engl J Med. 2015;372(6):579 - 581. doi:10.1056/NEJMc1415679
5. Sørensen HJ, Holst C, Knop J, Mortensen EL, tolstrup JS, becker U. Alcohol and delirium tremens: effects of average number of drinks per day and beverage type. Acta Psychiatr Scand. 2019;139(6):518 - 525. doi:10.1111/acps.13006
6. Burapakajornpong N, Maneeton B, Srisurapanont M. Pattern and risk factors of alcohol withdrawal delirium. J Med Assoc Thail Chotmaihet Thangphaet. 2011;94:991 - 997.
7. Wetterling T, Kanitz R - D, veltrup C, Driessen M. Clinical Predictors of Alcohol Withdrawal Delirium. Alcohol Clin Exp Res. 1994;18(5):1100 - 1102. doi:10.1111/j.1530 - 0277.1994.tb00087.x
8. Khan A, Levy P, DeHorn S, Miller W, Compton S. Predictors of Mortality in Patients with Delirium Tremens. Acad Emerg Med. 2008;15(8):788 - 790. doi:10.1111/j.1553 - 2712.2008.00187.x
9. Jesse S, bråthen G, Ferrara M, et al. Alcohol withdrawal syndrome: mechanisms, manifestations, and management. Acta Neurol Scand. 2017;135(1):4 - 16. doi:10.1111/ane.12671
10. Hughes JR. Alcohol withdrawal seizures. Epilepsy Behav. 2009;15(2):92 - 97.
11. Max B, Jonah M, Keith RH, Jack W. Alcohol Withdrawal Syndrome. Am Fam Physician. 2004;69(6):1443 - 1450.
12. Schuckit MA, tipp JE, Reich T, Hesselbrock VM, bucholz KK. The histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects. Addiction. 1995;90(10):1335 - 1347. doi:10.1046/j.1360 - 0443.1995.901013355.x
13. Singh P, Shrestha D, Gautam S, Swar S, Joshi N. Assessment of characteristics of patient with delirium tremens. Nepal Med Coll J NMCJ. 2012;14:216 - 218.
14. Sarkar S, Choudhury S, Ezhumalai G, Konthoujam J. Risk factors for the development of delirium in alcohol dependence syndrome: Clinical and neurobiological implications. Indian J Psychiatry. 2017;59(3):300 - 305. doi:10.4103/psychiatry.IndianJPsychiatry_67_17
15. Monte R, Rabuñal R, Casariego E, bal M. Risk factors for delirium tremens in patients with alcohol withdrawal syndrome in a hospital setting. Eur J Intern Med. 2009;20(7):690 - 694.
16. Graef J, Huitt T, Nordskog B, Hammarback J, Godwin D. Disrupted Thalamic T - Type Ca2+ Channel Expression and Function During Ethanol Exposure and Withdrawal. J Neurophysiol. 2011;105:528 - 540. doi:10.1152/jn.00424.2010