Single nucleotide polymorphism rs2596542 and MICA/B expression in nasopharyngeal carcinoma

Vu Hai Linh, Nguyen Tan Dong, Nguyen Hoang Viet, Nguyen Minh Ngoc, Tran Ngoc Minh, Nguyen Kim Dong, Tran Van Khanh, Ta Thanh Dat, Nguyen Quy Linh

Main Article Content

Abstract

 Major histocompatibility complex class I chain-related A/B (MICA/B) are tumor antigens.
MICA/B are greatly expressed in human on the surface of malignant cancerous cells and trigger
immune system response. This study was conducted to identify the genetic variant rs2596542
C>T in regulating MICA/B expression in nasopharyngeal carcinoma (NPC). A total of 58 tumor
tissues from nasopharyngeal carcinoma patients were examined in this study. Single nucleotide
polymorphism (SNP) association was determined by genotyping real-time PCR. MICA/B protein
expression was quantified by performing immunohistochemistry staining. Tumors derived from CC
genotype had the lowest MICA/B expression (p = 0.03). Tumors derived from rs2596542T allele
had greater MICA/B expression levels than those with tumors with the rs2596542C allele (p =
0.04). Levels of MICA/B expression in NPC tissue were highly correlated with the patients who
carried the T allele of rs2596542. The high-risk T allele of rs2596542 on the MICA gene and level
of MICA/B protein expression can become potential targets for immunotherapy treatment in NPC.

Article Details

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