The expression of alpha-synuclein induced defects in drosophila locomotive ability
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Abstract
Parkinson’s disease is one of the most common neuro-degenerative disease characterized by impaired locomotive ability. The morphological of this disease is degeneration of doparminergic in the substantia nigra and accumulation of Lewy body in the peripheral autonomic nervous system. There are many risk factors for Parkinson’s disease, in which genetic factors associated with abnormal expression of the protein alpha-synuclein are considered to be the main cause of the early onset. In this study, we used the GAL4/UAS system to express the protein alpha-synuclein in brain tissue and to evaluate the effect of this protein expression on locomotive ability and longevity of fruit flies. The results showed that the fruit flies expressing the protein alpha-synuclein had dyskinesia in both larval and adult stage; with age, the locomotive ability impairment increased. Furthermore, the average life expectancy decreased significantly compared to the control group. This model promises application for studying pathogenesis mechanism and drug screening for Parkinson’s disease treatment.
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Keywords
Parkinson disease, alpha-synuclein, Drosophila, …
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