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Published: 2022-06-11
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DOI: https://doi.org/10.52852/tcncyh.v154i6.684
Issue
Vol. 154 No. 6 (2022): Tập 154 số 6 E10
Section
Các bài báo
How to Cite
Anh, P. T. V., Hang, V. V., Ngoan, D. T., Nguyet, T. M., & Hang, D. T. T. (2022). 1. Safety evaluation of mulberry powder: Assessment of subchronic toxicity in rats. Journal of Medical Research, 154(6), 1-9. https://doi.org/10.52852/tcncyh.v154i6.684

1. Safety evaluation of mulberry powder: Assessment of subchronic toxicity in rats

Pham Thi Van Anh, Vu Viet Hang, Dao Thi Ngoan, Ta Minh Nguyet, Dinh Thi Thu Hang

Main Article Content

Abstract

Obesity has reached epidemic proportions globally, with at least 2.8 million people dying each year due to being overweight or obese. Because of the botamical's chemical diversity and the ability to act on various biological targets, plant products have long been a thriving source for discovering new compounds to treat obesity. MULBERRY powder was a herbal-derived product combined with Amorphophallus konjac K. Koch starch and mulberry (Morus alba L.) leaves extract; these plants have long been used in Asia as food sources and as traditional medicines. So far, the safety of this product has not been reported yet in the world and Vietnam. Thus, this study was designed to assess the subchronic toxicity of MULBERRY powder in Wistar rats. The method used in this study followed the guidance of the World Health Organization and Organization for Economic Co-operation and Development in rats with two oral doses of 1.2 g/kg b.w/day and 3.6 g/kg b.w/day for 12 consecutive weeks. As a result, MULBERRY powder at both doses caused no significant changes in body weight, hematological indexes, functions, and microscopic images of livers and kidneys, although MULBERRY powder at 3.6 g/kg b.w/day caused diarrhea at about 20% of rats. In conclusion, MULBERRY powder did not cause subchronic toxicity in experimental rats. However, this partly revealed the safety of MULBERRY powder in clinical practice.


 

Article Details

Keywords

MULBERRY powder, Amorphophalus konjac K. Koch, Morus alba L., subchronic toxicity, rats

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