Lâm sàng, cận lâm sàng và mối liên quan của các tổn thương mạch máu ở bệnh nhân xơ cứng bì hệ thống

Abstract

This research was performed to investigate the clinical, subclinical features and correlation of peripheral vascular disease and pulmonary arterial hypertension in patients with systemic sclerosis. This was a cross-sectional study of 71 patients with systemic sclerosis. 100% of patients had nailfold microvascular impairment on capillaroscopy and most were in the early stage, accounting for 47.9%; the total capillaroscopy score was 3.3 ± 1.2. 98.6% of patients had Raynaud's phenomenon and the average process duration of Raynaud's phenomenon was 38.0 ± 37.2 months and the average Raynaud's condition score was 3.9 ± 1.5 points; 6 patients accounting for 8.5% had active digital ulcers; the average quantity of digital pitting scars was 1.1 ± 1.4. The mean systolic pulmonary artery pressure was 40.2 ± 5.1 mmHg. The majority of patients with WHO functional classification belonged to group II, accounting for 53.5%. The WHO functional classification mean was 2.0 ± 0.7. There was no correlation between pulmonary arterial pressure value and RCS, number of active digital ulcers and semi-quantitative nailfold capillaroscopic score of loss of capillaries with p>0.05. All patients had peripheral vascular disease on subclinical and nearly all showed clinical symptoms. Systolic pulmonary artery pressure was not too elevated and most patients had only mild symptoms. There was no correlation between pulmonary arterial hypertension and peripheral vascular diseases.