Serotypes of Enterovirus Causing Hand, Foot and Mouth Disease at National Children's Hospital in 2018 - 2019

Nguyen Van Lam, Nguyen Phuong Hanh

Main Article Content

Abstract

In addition to EV71 and Coxsackie A16 (CA16), other serotypes of Enterovirus (EV) can also cause hand, foot, and mouth disease (HFMD). This study aims to identify serotypes of EV causing HFMD in inpatients at the National Children's Hospital. This is a cross-sectional descriptive study of 156 patients with confirmed diagnosis of HFMD (clinical and RT-PCR EV positive) treated at the National Children's Hospital from May 1, 2018 to April 30, 2019. As a result, 17 serotypes of EV causing HFMD were identified, distributed in all groups of human EV. EV71 accounted for the highest percentage (68.6%), followed by CA6 (10.9%). Our research study have successfully sequenced 42/107 EV71 specimens (39.25%) and identified almost all EV71 in 2018-2019 belonging to subgenogroup C4.

Article Details

References

1. WHO - Western Pacific Region. A Guide to Clinical Management and Public Health Response for Hand, Foot and Mouth Disease (HFMD). Manila: WHO Regional Office for the Western Pacific; 2011.
2. Lee MS, Tseng FC, Wang JR, Chi CY, Chong P, Su IJ. Challenges to Licensure of Enterovirus 71 Vaccines. Diemert DJ, ed. PLoS Neglected Tropical Diseases. 2012;6(8):e1737. doi:10.1371/journal.pntd.0001737
3. Nguyễn Thị Hồng Lạc. Nghiên cứu hiệu quả của Imunoglobulin trong điều trị bệnh tay chân miệng trẻ em tại bệnh viện Nhi Trung ương. [Luận văn chuyên khoa II]. Hà Nội: Trường Đại học Y Hà Nội; 2012.
4. Nikonov OS, Chernykh ES, Garber MB, Nikonova EYu. Enteroviruses: Classification, diseases they cause, and approaches to development of antiviral drugs. Biochemistry Moscow. 2017;82(13):1615-1631. doi:10.1134/S0006297917130041
5. Nguyễn Thị Hiền Thanh, Trần Thị Nguyễn Hòa, Vũ Hồng Nga, Đào Thị Hải Anh. Bệnh tay chân miệng ở người năm 2008 do virus đường ruột typ71 và virus coxsackie A 16. Tạp chí Y học dự phòng. 2010;6(114):47-51.
6. Chen Q, Zhang Q, Hu Z. Profiles of Human Enteroviruses Associated with Hand, Foot, and Mouth Disease in Nanjing, China. Disaster Medicine and Public Health Preparedness. 2019;13(04):740-744. doi:10.1017/dmp.2018.155
7. Van Tu P, Thao NTT, Perera D, et al. Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005. Emerging Infectious Diseases. 2007;13(11):1733-1741. doi:10.3201/eid1311.070632
8. Khanh TH, Sabanathan S, Thanh TT, et al. Enterovirus 71–associated Hand, Foot, and Mouth Disease, Southern Vietnam, 2011. Emerging Infectious Diseases. 2012;18(12):2002-2005. doi:10.3201/eid1812.120929
9. Li J, Yang Z, Wang Z, et al. The surveillance of the epidemiological and serotype characteristics of hand, foot, mouth disease in Neijiang city, China, 2010-2017: A retrospective study. Bessaud M, ed. PLOS ONE. 2019;14(6):e0217474. doi:10.1371/journal.pone.0217474
10. Chen KT, Chang HL, Wang ST, Cheng YT, Yang JY. Epidemiologic Features of Hand-Foot-Mouth Disease and Herpangina Caused by Enterovirus 71 in Taiwan, 1998 2005. PEDIATRICS. 2007;120(2):e244-e252. doi:10.1542/peds.2006-3331
11. Nguyễn Kim Thư. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và căn nguyên vi rút gây bệnh Tay Chân Miệng tại Việt Nam. [Luận án tiến sĩ]. Hà Nội: Trường Đại học Y Hà Nội; 2016.
12. Takechi M, Fukushima W, Nakano T, et al. Nationwide Survey of Pediatric Inpatients With Hand, Foot, and Mouth Disease, Herpangina, and Associated Complications During an Epidemic Period in Japan: Estimated Number of Hospitalized Patients and Factors Associated With Severe Cases. Journal of Epidemiology. 2019;29(9):354-362. doi:10.2188/jea.JE20180060
13. Wang SM, Liu CC. Update of enterovirus 71 infection: epidemiology, pathogenesis and vaccine. Expert Review of Anti-infective Therapy. 2014;12(4):447-456. doi:10.1586/14787210.2014.895666
14. Tuan LV, Tuyet Van NT, Quan NH, Duoc PT. Molecular epidemiology analysis of enterovirus 71 strains isolated in Dak Lak, Vietnam, 2011-2016. Journal of Medical Virology. Published online August 21, 2018. doi:10.1002/jmv.25286
15. Zhang Y, Wang J, Guo W, et al. Emergence and Transmission Pathways of Rapidly Evolving Evolutionary Branch C4a Strains of Human Enterovirus 71 in the Central Plain of China. Jin DY, ed. PLoS ONE. 2011;6(11):e27895. doi:10.1371/journal.pone.0027895
16. Wu JS, Zhao N, Pan H, et al. Patterns of polymorphism and divergence in the VP1 gene of enterovirus 71 circulating in the Asia-Pacific region between 1994 and 2013. Journal of Virological Methods. 2013;193(2):713-728. doi:10.1016/j.jviromet.2013.07.051