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Published: 2021-05-31
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DOI: https://doi.org/10.52852/tcncyh.v138i2.73
Issue
Vol. 138 No. 2 (2021)
Section
Các bài báo
How to Cite
Anh, P. T. V., Hoa, H. Q., Giang, P. T. L., Kim, L. T., Quang, L. A., & Thanh, M. P. (2021). Hypouricemic action of vitagout capsules on potassium oxonate-induced elevation of blood uric acid concentration. Journal of Medical Research, 138(2), 63-68. https://doi.org/10.52852/tcncyh.v138i2.73

Hypouricemic action of vitagout capsules on potassium oxonate-induced elevation of blood uric acid concentration

Phạm Thị Vân Anh, Hoàng Quỳnh Hoa, Phạm Thị Linh Giang, Lê Thiên Kim, Lê Anh Quang, Mai Phương Thanh

Main Article Content

Abstract

This study assessed the effects of VitaGout at the doses of 1.2 g herbal raw materials/day and 3.6 g herbal raw materials/day on the serum uric acid level  in animal model of hyperuricemia using mice pretreated with the uricase inhibitor potassium oxonate. The mice were intragastrically administered with drugs once a day for 5 consecutive daysin order to determine their concentration of uric acid in serum and urine, and fractional excretion of uric acid. Subsequently, induced elevation of blood uric acid level was done by administering oxonate at 500mg/kg. VitaGout dose of 3.6 herbal raw materials/day significantly lowered blood uric acid level. In addition, both test doses of VitaGout significantly lowered the urine uric acid levels and fractional excretion of uric acid. These results demonstrated the hypouricemic action of VitaGout at the dose of 3.6 g herbal raw materials/day, which might not be associated with uricosuric activity.

Article Details

Keywords

VitaGout, uric acid, mice.

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