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Published: 2022-02-22
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DOI: https://doi.org/10.52852/tcncyh.v150i2.737
Issue
Vol. 150 No. 2 (2022)
Section
Các bài báo
How to Cite
Thành, N. T. M., Đô, N. V. ., Sơn, H. A. ., & Toàn, N. L. . (2022). Establishment of human non small cell lung cancer on experimental model. Journal of Medical Research, 150(2), 182-188. https://doi.org/10.52852/tcncyh.v150i2.737

Establishment of human non small cell lung cancer on experimental model

Nguyen Thi My Thanh, Nguyen Van Do, Ho Anh Son, Nguyen Linh Toan

Main Article Content

Abstract

Human xenograft tumor models established by transplantation of human cancer cell lines into immunodeficient mice are used for preclinical test of new anticancer agents in vivo. This study aimed to create human non-small cell lung cancer on immunodeficient nude mice (Nude mice) by the H460 human cancer cell line. H460 cells were injected into the right flanks of nude mice with 0.1ml × 107 cells per mouse. Then, tumor growth rate, tumor volume, tumor regression rate, survival-death rate, and tumor histology, were collected. Results: 100% nude mouse has tumor growth, no death due to technical error. The histological image is similar to the patient tumor. In conclusion, we successfully established human non-small cell lung cancer on the immunodeficient nude mouse.

Article Details

Author Biography

Nguyen Thi My Thanh,

Phó Trưởng Bộ môn Sinh lý bệnh -Miễn dịch Trường ĐH Y Khoa Vinh

Keywords

H460, non-small cell lung cancer, nude mice

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