Sub-chronic oral toxicity study of “Phong Thap Dan” tablets in experimental animal
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Tóm tắt
The present study aimed to investigate the sub-chronic toxicity of “Phong thap dan” (PTD) tablets through oral administration in experimental animal. The sub-chronic toxicity was evaluated by the WHO recommendation in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose). In the sub-chronic experimental group, the PTD was administered orally daily for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no behavioral and physiological change or sign of toxicity. The result of the hematological and biological parameters after administration of PTD tablets showed no change. The histopathology analysis of livers and kidneys indicated that no significant difference was observed between the exposed and unexposed rat groups. In conclusion, “Phong thap dan” tablets did not produce sub-chronic toxicity in Wistar rats.
Chi tiết bài viết
Từ khóa
“Phong thap dan” tablet, sub-chronic toxicity, Wistar rats
Tài liệu tham khảo
2. Zhang X, Zhan G, Jin M, et al. Botany, traditional use, phytochemistry, pharmacology, quality control, and authentication of Radix Gentianae Macrophyllae -A traditional medicine: A review. Phytomedicine. 2018;46:142-163.
3. Li Y, Liu Y, Shao Y, et al. Mechanism of action of strychnin semen for treating Rheumatoid arthritis and methods for attenuating the toxicity. Comb Chem High Throughput Screen; Published online May 3, 2021.
4. Hong Y-H, Weng L-W, Chang C-C, et al. Anti-Inflammatory Effects of Siegesbeckia orientalis Ethanol Extract in In Vitro and In Vivo Models. BioMed Res Int. 2014;2014:329712.
5. Beg S, Swain S, Hasan H, Barkat MA, Hussain MS. Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. Pharmacogn Rev. 2011;5(10):120-137.
6. Organization WH. WHO Guidelines for Assessing Quality of Herbal Medicines with Reference to Contaminants and Residues. World Health Organization; 2007. Accessed June 27, 2021.
7. Mensah MLK, Komlaga G, Forkuo AD, Firempong C, Anning AK, Dickson RA. Toxicity and Safety Implications of Herbal Medicines Used in Africa. IntechOpen. 2019.
8. Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents. OECD; Accessed July 5, 2021.
9. Nutrition C for FS and A. Redbook 2000: IV.C.4.a. Subchronic Toxicity Studies with Rodents. U.S. Food and Drug Administration; Published April 11, 2019. Accessed July 6, 2021.
10. Hilaly JE, Israili ZH, Lyoussi B. Acute and chronic toxicological studies of Ajuga iva in experimental animals. J Ethnopharmacol. 2004;91(1):43-50.
11. Toxic Responses of the Blood. Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition. AccessPharmacy. McGraw Hill Medical; Accessed July 6, 2021.
12. Fan Y, Liu S, Chen X, Feng M, Song F, Gao X. Toxicological effects of Nux Vomica in rats urine and serum by means of clinical chemistry, histopathology and 1H NMR-based metabonomics approach. J Ethnopharmacol. 2018;210:242-253.
13. Nguyen Thi Thanh Tu. Study on the safety and effectiveness of Hoang Kinh hard capsules for the treatment of rheumatoid arthritis. Published online 2016.